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A step\u2010wise therapeutic approach is employed for periodontitis. After an initial behavioral and non\u2010surgical phase, intra\u2010bony or furcation defects may be amenable to regenerative procedures. This review discusses the regenerative technologies employed for periodontal regeneration, highlighting the current limitations and future research areas. The search, performed on the MEDLINE database, has identified the available biomaterials, including biologicals (autologous platelet concentrates, hydrogels), bone grafts (pure or putty), and membranes. Biologicals and bone grafts have been critically analyzed in terms of composition, mechanism of action, and clinical applications. Although a certain degree of periodontal regeneration is predictable in intra\u2010bony and class II furcation defects, complete defect closure is hardly achieved. Moreover, treating class III furcation defects remains challenging. The key properties required for functional regeneration are discussed, and none of the commercially available biomaterials possess all the ideal characteristics. Therefore, research is needed to promote the advancement of more effective and targeted regenerative therapies for periodontitis. Lastly, improving the design and reporting of clinical studies is suggested by strictly adhering to the Consolidated Standards of Reporting Trials (CONSORT) 2010 statement.<\/jats:p>","DOI":"10.1002\/advs.202308848","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T05:03:32Z","timestamp":1708491812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["From Basic Science to Clinical Practice: A Review of Current Periodontal\/Mucogingival Regenerative Biomaterials"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5111-1398","authenticated-orcid":false,"given":"Angela","family":"De Lauretis","sequence":"first","affiliation":[{"name":"Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Dentistry University of Oslo  Oslo 0455 Norway"},{"name":"Department of Chemistry, Materials and Chemical Engineering \u201cGiulio Natta\u201d Politecnico di Milano  Milan 20133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9170-0202","authenticated-orcid":false,"given":"\u00d8ystein","family":"\u00d8vreb\u00f8","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Dentistry University of Oslo  Oslo 0455 Norway"},{"name":"Department of Chemistry, Materials and Chemical Engineering \u201cGiulio Natta\u201d Politecnico di Milano  Milan 20133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-083X","authenticated-orcid":false,"given":"Mario","family":"Romandini","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Institute of Clinical Dentistry, Faculty of Dentistry University of Oslo  Oslo 0455 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6361-7644","authenticated-orcid":false,"given":"St\u00e5le Petter","family":"Lyngstadaas","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Dentistry University of Oslo  Oslo 0455 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2665-120X","authenticated-orcid":false,"given":"Filippo","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Materials and Chemical Engineering \u201cGiulio Natta\u201d Politecnico di Milano  Milan 20133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6690-7233","authenticated-orcid":false,"given":"H\u00e5vard Jostein","family":"Haugen","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Dentistry University of Oslo  Oslo 0455 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12946"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.38"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2009.0562"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.22812"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800457"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32154-2"},{"key":"e_1_2_8_7_1","first-page":"1","volume":"2020","author":"Nazir M.","year":"2020","journal-title":"The Scientific World Journal"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21-0276"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12732"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515602879"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2012.00457.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13813"},{"key":"e_1_2_8_13_1","author":"Marruganti C.","year":"2023","journal-title":"J. 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