{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:33:11Z","timestamp":1792636391918,"version":"4.5.0"},"reference-count":60,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974340"],"award-info":[{"award-number":["81974340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172455"],"award-info":[{"award-number":["82172455"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M732289"],"award-info":[{"award-number":["2023M732289"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A recently emerging cell death pathway, known as copper\u2010induced cell death, has demonstrated significant potential for treating infections. Existing research suggests that cells utilizing aerobic respiration, as opposed to those reliant on glycolysis, exhibit greater sensitivity to copper\u2010induced death. Herein, a MnO<jats:sub>2<\/jats:sub>\u2010loaded copper metal\u2013organic frameworks platform is developed denoted as MCM, to enhance bacterial cuproptosis\u2010like death via the remodeling of bacterial respiratory metabolism. The reversal of hypoxic microenvironments induced a cascade of responses, encompassing the reactivation of suppressed immune responses and the promotion of osteogenesis and angiogenesis. Initially, MCM catalyzed O<jats:sub>2<\/jats:sub> production, alleviating hypoxia within the biofilm and inducing a transition in bacterial respiration mode from glycolysis to aerobic respiration. Subsequently, the sensitized bacteria, characterized by enhanced tricarboxylic acid cycle activity, underwent cuproptosis\u2010like death owing to increased copper concentrations and aggregated intracellular dihydrolipoamide S\u2010acetyltransferase (DLAT). The disruption of hypoxia also stimulated suppressed dendritic cells and macrophages, thereby strengthening their antimicrobial activity through chemotaxis and phagocytosis. Moreover, the nutritional effects of copper elements, coupled with hypoxia alleviation, synergistically facilitated the regeneration of bones and blood vessels. Overall, reshaping the infection microenvironment to enhance cuproptosis\u2010like cell death presents a promising avenue for eradicating biofilms.<\/jats:p>","DOI":"10.1002\/advs.202308850","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T07:00:01Z","timestamp":1710313201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Enhanced Bacterial Cuproptosis\u2010Like Death via Reversal of Hypoxia Microenvironment for Biofilm Infection Treatment"],"prefix":"10.1002","volume":"11","author":[{"given":"Zhiyuan","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  600 Yishan Road Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  600 Yishan Road Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingwang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  600 Yishan Road Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zesong","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  600 Yishan Road Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  600 Yishan Road Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  600 Yishan Road Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeming","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  600 Yishan Road Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  600 Yishan Road Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  600 Yishan Road Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  600 Yishan Road Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1612-5794","authenticated-orcid":false,"given":"Yunfeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  600 Yishan Road Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202207961"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202004010"},{"key":"e_1_2_8_1_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04317-2"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0019-y"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c09599"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121249"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00122-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202006357"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202004788"},{"key":"e_1_2_8_4_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201712878"},{"key":"e_1_2_8_4_4","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202303989"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c11550"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c05075"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf0529"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202213922"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202204733"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202303432"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.10.032"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202000398"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2023.06.024"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2017.11.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2022.01.002"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002213"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12476"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12458"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00518"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29659-1"},{"key":"e_1_2_8_13_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310320"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c10660"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.04.008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120593"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27217-4"},{"key":"e_1_2_8_15_3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00011"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c01023"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122179"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202001549"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120853"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.07.046"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c07200"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110792"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b04496"},{"key":"e_1_2_8_20_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b10459"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121597"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06882-y"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225561"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12401"},{"key":"e_1_2_8_23_1","first-page":"1","volume":"75","author":"Balasubramanian D.","year":"2017","journal-title":"Pathog. Dis."},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b21766"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b17815"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202107300"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32405-x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB02615A"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100426"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300313"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119833"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121751"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202104410"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.3c00499"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202206545"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c00598"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202308850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:15:53Z","timestamp":1759958153000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202308850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,13]]},"references-count":60,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/advs.202308850"],"URL":"https:\/\/doi.org\/10.1002\/advs.202308850","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,13]]},"assertion":[{"value":"2023-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2308850"}}