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It overcomes the challenges of chemoselectivity and enantioselectivity, achieving a highly enantioselective vicinal sulfonyl\u2010esterification reaction of alkenes involving sulfur dioxide. This strategy involves the use of earth\u2010abundant metal catalyst, mild reaction conditions, a broad range of substrates (84 examples), high yields (up to 97% yield), and exceptional control over enantioselectivity. The reaction system is compatible with different types of radical precursors, including\n                    <jats:italic>O<\/jats:italic>\n                    \u2010acylhydroxylamines, cycloketone oxime esters, aryldiazonium salts, and drug molecules. Chiral ligand PyBim is identified as particularly effective in achieving the desired high enantioselectivity. Mechanistic studies reveal that copper\/PyBim system plays a vital role in C\u2500O coupling, employing an outer\u2010sphere model. In addition, the side arm effect of ligand is observed.\n                  <\/jats:p>","DOI":"10.1002\/advs.202309069","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:46:41Z","timestamp":1711500401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Three\u2010Component Radical Cross\u2010Coupling: Asymmetric Vicinal Sulfonyl\u2010Esterification of Alkenes Involving Sulfur Dioxide"],"prefix":"10.1002","volume":"11","author":[{"given":"Zhiqian","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Dermatology State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University  Chengdu 610041 P. R. 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