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Here, early auditory development is examined using repeated optical imaging for cochlear implanted (CI) toddlers with congenital deafness from onset of restored hearing to around one year of CI hearing experiences. Machine learning models are constructed to resolve how functional organization of the bilateral language network and its sound processing support the CI children's post\u2010implantation development of auditory and verbal communication skills. Behavioral improvement is predictable by cortical processing as well as by network organization changes, with the highest classification accuracy of 81.57%. For cortical processing, behavioral prediction is better for the left than the right hemisphere and for speech than non\u2010speech processing. For network organization, the best prediction is obtained for resting state, with greater contribution from inter\u2010hemisphere connections between non\u2010homologous regions than from within\u2010hemisphere connections. Most interestingly, systematic connectivity\u2010to\u2010activity models reveal that speech processing of the left language network is developmentally supported largely by global network organization, particularly asymmetric inter\u2010hemisphere communication, rather than functional segregation of local network. These findings collectively confirm the importance of asymmetric inter\u2010hemisphere communication in formation of the lateralized language network and its functional development with early auditory experiences.<\/jats:p>","DOI":"10.1002\/advs.202309194","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T14:52:59Z","timestamp":1743519179000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Asymmetric Inter\u2010Hemisphere Communication Contributes to Speech Acquisition of Toddlers with Cochlear Implants"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9577-4145","authenticated-orcid":false,"given":"Xue","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University  Beijing 100875 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiyun","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University  Beijing 100875 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haotian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery West China Hospital of Sichuan University  Chengdu 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Hunan Provincial People's Hospital (First Affiliated Hospital of Hunan Normal University)  Changsha 410005 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhikai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing 100025 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhe","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing Friendship Hospital Capital Medical University  Beijing 100050 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-7447","authenticated-orcid":false,"given":"Yu\u2010Xuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University  Beijing 100875 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cognition.2003.10.011"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2113"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-021-02256-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2891-18.2019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copsyc.2021.10.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1212220110"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3980-15.2016"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc9155"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.71.2.F81"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2020.109984"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.929199"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11111439"},{"key":"e_1_2_9_13_1","unstructured":"S.Zimmerman\u2010Phillips International Cochlear Conference."},{"key":"e_1_2_9_14_1","first-page":"312","volume":"166","author":"Archbold S.","year":"1995","journal-title":"Ann. 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