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Magnetic resonance imaging (MRI) has shown superior results to other examinations in preoperative assessment, while cisplatin\u2010based chemotherapy is the first\u2010line treatment for OC. However, few previous studies have brought together the two rapidly expanding fields. Here a technique is presented using cisplatin prodrug (Pt\u2010COOH), Fe<jats:sup>3+<\/jats:sup>, and natural polyphenols (Gossypol) to construct the nanoparticles (HA@PFG NPs) that have a stable structure, controllable drug release behavior, and high drug loading capacity. The acidic pH values in tumor sites facilitate the release of Fe<jats:sup>3+<\/jats:sup>, Pt\u2010COOH, and Gossypol from HA@PFG NPs. Pt\u2010COOH with GSH consumption and cisplatin\u2010based\u00a0chemotherapy plus Gossypol with pro\u2010apoptotic effects displays a\u00a0synergistic\u00a0effect for\u00a0killing\u00a0tumor\u00a0cells. Furthermore, the release of Fe<jats:sup>3+<\/jats:sup> at the tumor sites promotes ferroptosis and enables MRI imaging of OC. In\u00a0the patient\u2010derived tumor xenograft (PDX)\u00a0model, HA@PFG NPs alleviate the tumor activity. RNA sequencing analysis reveals that HA@PFG NPs ameliorate OC symptoms mainly through IL\u20106 signal pathways. This work combines MRI imaging with cisplatin\u2010based chemotherapy, which holds great promise for OC diagnosis and synergistic therapy.<\/jats:p>","DOI":"10.1002\/advs.202309464","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T15:39:52Z","timestamp":1726587592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Highly Efficient Synergistic Chemotherapy and Magnetic Resonance Imaging for Targeted Ovarian Cancer Therapy Using Hyaluronic Acid\u2010Coated Coordination Polymer Nanoparticles"],"prefix":"10.1002","volume":"11","author":[{"given":"Guang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The Third Affiliated Hospital Southern Medical University  Guangzhou 510630 China"},{"name":"Department of Gynecological Oncology and Cervical Lesions Hunan Provincial Maternal and Child Health Care Hospital  Changsha 410013 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