{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:26:09Z","timestamp":1786976769131,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51925308"],"award-info":[{"award-number":["51925308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1304000"],"award-info":[{"award-number":["2022YFA1304000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Easy injection, long\u2010lasting barrier, and drug loading are the critical properties of submucosal injection materials for endoscopic surgery. However, conventional injectable polymers face challenges in simultaneously attaining these properties due to the inherent conflict between injectability and in situ stability. Here, a multi\u2010arm star polymer hydrogel (denoted as \u03b2CP hydrogel) with long\u2010lasting submucosal barrier (exceeding 120 min), rapid hemostasis, and sustained antibacterial properties is successfully developed by grafting poly(oligo(ethylene glycol) methyl ether methacrylate)\u00a0(PEGMA) side\u2010chains from \u03b2\u2010CD via atom transfer radical polymerization (ATRP). During the onset of shearing, \u03b2CP hydrogel experiences the unwinding of polymer side\u2010chains between neighboring star polymers, which facilitates the process of endoscopic injectability. After submucosal injection, \u03b2CP hydrogel undergoes the winding of polymer side\u2010chains, thereby establishing a long\u2010lasting barrier cushion. Meanwhile, owing to its distinctive structures with a hydrophobic inner cavity and an outer layer of hydrophilic polymer side\u2010chains, \u03b2CP hydrogel enables simultaneous loading and on\u2010demand release of diverse categories of\u00a0drugs. This unique performance can adapt to the diverse demands during different stages of wound healing in a porcine endoscopic surgery model. These results indicate an appealing prospect for new application of star polymers as a good submucosal injection material in endoscopic treatments.<\/jats:p>","DOI":"10.1002\/advs.202309586","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T03:44:36Z","timestamp":1714448676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Synergistic Drug\u2010Loaded Shear\u2010Thinning Star Polymer Hydrogel Facilitates Gastrointestinal Lesion Resection and Promotes Wound Healing"],"prefix":"10.1002","volume":"11","author":[{"given":"Yue","family":"Zhang","sequence":"first","affiliation":[{"name":"PCFM Lab School of Chemistry Sun Yat\u2010sen University  Guangzhou 510006 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongtian","family":"Miao","sequence":"additional","affiliation":[{"name":"PCFM Lab School of Chemistry Sun Yat\u2010sen University  Guangzhou 510006 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingli","family":"Su","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Endoscopic Surgery) Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases Biomedical Innovation Center Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat\u2010sen University) Ministry of Education  Guangzhou 510655 P. R. China"},{"name":"The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinxiang","family":"Tang","sequence":"additional","affiliation":[{"name":"PCFM Lab School of Chemistry Sun Yat\u2010sen University  Guangzhou 510006 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Endoscopic Surgery) Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases Biomedical Innovation Center Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat\u2010sen University) Ministry of Education  Guangzhou 510655 P. R. China"},{"name":"The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1396-0097","authenticated-orcid":false,"given":"Dingcai","family":"Wu","sequence":"additional","affiliation":[{"name":"PCFM Lab School of Chemistry Sun Yat\u2010sen University  Guangzhou 510006 P. R. 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