{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:42:47Z","timestamp":1790739767534,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52173118"],"award-info":[{"award-number":["52173118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51973041"],"award-info":[{"award-number":["51973041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2703704"],"award-info":[{"award-number":["2022YFC2703704"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The escalating spread of drug\u2010resistant bacteria and viruses is a grave concern for global health. Nucleic acids dominate the drug\u2010resistance and transmission of pathogenic microbes. Here, imidazolium\u2010type poly(ionic liquid)\/porphyrin (PIL\u2010P) based electrospun nanofibrous membrane and its cerium (IV) ion complex (PIL\u2010P\u2010Ce) are developed. The obtained PIL\u2010P\u2010Ce membrane exhibits high and stable efficiency in eradicating various microorganisms (bacteria, fungi, and viruses) and decomposing microbial antibiotic resistance genes and viral nucleic acids under light. The nuclease\u2010mimetic and photocatalytic mechanisms of the PIL\u2010P\u2010Ce are elucidated. Co\u2010infection wound models in mice with methicillin\u2010resistant <jats:italic>S. aureus<\/jats:italic> and hepatitis B virus demonstrate that PIL\u2010P\u2010Ce integrate the triple effects of cationic polymer, photocatalysis, and nuclease\u2010mimetic activities. As revealed by proteomic analysis, PIL\u2010P\u2010Ce shows minimal phototoxicity to normal tissues. Hence, PIL\u2010P\u2010Ce has potential as a \u201cgreen\u201d wound dressing to curb the spread of drug\u2010resistant bacteria and viruses in clinical settings.<\/jats:p>","DOI":"10.1002\/advs.202309590","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T09:35:10Z","timestamp":1713778510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Antimicrobial and Antiviral Nanofibers Halt Co\u2010Infection Spread via Nuclease\u2010Mimicry and Photocatalysis"],"prefix":"10.1002","volume":"11","author":[{"given":"Jieran","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine Zhongshan Hospital Fudan University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhong","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Chemistry Chemical Engineering and Materials Science Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Zhongshan Hospital Fudan University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Zhongshan Hospital Fudan University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangna","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Chemistry Chemical Engineering and Materials Science Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Chemistry Chemical Engineering and Materials Science Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongwei","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Material and Chemical Engineering Tongren University  Tongren 554300 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Zhongshan Hospital Fudan University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiateng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Chemistry Chemical Engineering and Materials Science Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-7142","authenticated-orcid":false,"given":"Hailei","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Zhongshan Hospital Fudan University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-022-12175-8"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3380"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.117402"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0348-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33661-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB01274B"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.04.007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201605296"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR07629A"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202100336"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.7b00185"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b03391"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900608"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.13.211"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c06071"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2020.111787"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04623.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b00629"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9DT00246D"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214417"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2011.653969"},{"key":"e_1_2_8_22_1","first-page":"13","volume":"107","author":"Cadet J.","year":"2017","journal-title":"Biol. Med."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1562\/2006-06-09-IR-914"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc30952a"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0083-y"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00195"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c10771"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202302943"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2012.03906.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM01130A"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.6b00644"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.05.013"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00573-0"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.10.013"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021109845"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.10.025"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.03.005"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC01260J"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00393-6"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101650"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101916"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.5b00319"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.impact.2019.100194"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.6b01802"},{"key":"e_1_2_8_45_1","first-page":"53","volume":"368","author":"Zhang X.","year":"2013","journal-title":"J. Mol. Catal. A: Chem."},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.732076"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq170"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202309590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:54:36Z","timestamp":1759784076000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202309590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":47,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/advs.202309590"],"URL":"https:\/\/doi.org\/10.1002\/advs.202309590","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,22]]},"assertion":[{"value":"2023-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2309590"}}