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Current strategies are primarily focused on the inhibition of bacterial activation while disregarding the excessive inflammation induced by dead bacteria remaining in the body and the effect of the acidic microenvironment during therapy. In this study, a novel dual\u2010functional MgB\n                    <jats:sub>2<\/jats:sub>\n                    microparticles integrated microneedle (MgB\n                    <jats:sub>2<\/jats:sub>\n                    MN) patch is presented to kill bacteria and eliminate dead bacteria for skin infection management. The MgB\n                    <jats:sub>2<\/jats:sub>\n                    microparticles not only can produce a local alkaline microenvironment to promote the proliferation and migration of fibroblasts and keratinocytes, but also achieve &gt;5 log bacterial inactivation. Besides, the MgB\n                    <jats:sub>2<\/jats:sub>\n                    microparticles effectively mitigate dead bacteria\u2010induced inflammation through interaction with lipopolysaccharide (LPS). With the incorporation of these MgB\n                    <jats:sub>2<\/jats:sub>\n                    microparticles, the resultant MgB\n                    <jats:sub>2<\/jats:sub>\n                    MN patches effectively kill bacteria and capture dead bacteria, thereby mitigating these bacteria\u2010induced inflammation. Therefore, the MgB\n                    <jats:sub>2<\/jats:sub>\n                    MN patches show good therapeutic efficacy in managing animal bacterial skin infections, including abscesses and wounds. These results indicate that reactive metal borides\u2010integrated microneedle patches hold great promise for the treatment of clinical skin infections.\n                  <\/jats:p>","DOI":"10.1002\/advs.202309622","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T19:52:08Z","timestamp":1712433128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Reactive Microneedle Patches with Antibacterial and Dead Bacteria\u2010Trapping Abilities for Skin Infection Treatment"],"prefix":"10.1002","volume":"11","author":[{"given":"Jingyang","family":"Shan","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"},{"name":"Key Laboratory of Organic Electronics and Information Displays Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Nanjing University of Posts and Telecommunications  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 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