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In this work, a phosphoric acid\u2010catalyzed enantioselective synthesis of \u03b1,\u03b1\u2010diaryl aldehydes from simple terminal alkynes is presented. This approach yields a wide range of highly enolizable \u03b1,\u03b1\u2010diaryl aldehydes in good yields with excellent enantioselectivities. Facile transformations of the products, as well as an efficient synthesis of bioactive molecules, including an effective anti\u2010smallpox agent and an FDA\u2010approved antidepressant drug (+)\u2010sertraline, are demonstrated.<\/jats:p>","DOI":"10.1002\/advs.202309645","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:43:58Z","timestamp":1713833038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Catalytic Asymmetric Construction of \u03b1,\u03b1\u2010Diaryl Aldehydes via Oxo\u2010Hydroarylation of Terminal Alkynes"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6847-5366","authenticated-orcid":false,"given":"Xueting","family":"Zhou","sequence":"first","affiliation":[{"name":"Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University  Binhai New City Fuzhou 350207 China"},{"name":"Department of Chemistry National University of Singapore  3 Science Drive 3 Singapore 117543 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqin","family":"Huang","sequence":"additional","affiliation":[{"name":"Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University  Binhai New City Fuzhou 350207 China"},{"name":"Department of Chemistry National University of Singapore  3 Science Drive 3 Singapore 117543 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiami","family":"Guo","sequence":"additional","affiliation":[{"name":"Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University  Binhai New City Fuzhou 350207 China"},{"name":"Department of Chemistry National University of Singapore  3 Science Drive 3 Singapore 117543 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-7408","authenticated-orcid":false,"given":"Lei","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Chemistry National University of Singapore  3 Science Drive 3 Singapore 117543 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5730-166X","authenticated-orcid":false,"given":"Yixin","family":"Lu","sequence":"additional","affiliation":[{"name":"Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University  Binhai New City Fuzhou 350207 China"},{"name":"Department of Chemistry National University of Singapore  3 Science Drive 3 Singapore 117543 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"e_1_2_7_1_1","volume-title":"Organic Synthesis","author":"Smith M. 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These data are provided free of charge by the Cambridge Crystallographic Data Centre."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901446n"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.7b03388"},{"key":"e_1_2_7_13_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201302349"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja9092264"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0020-0"},{"key":"e_1_2_7_14_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201905021"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202309645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:54:39Z","timestamp":1759784079000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202309645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":34,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/advs.202309645"],"URL":"https:\/\/doi.org\/10.1002\/advs.202309645","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,22]]},"assertion":[{"value":"2023-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2309645"}}