{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T11:58:39Z","timestamp":1793361519798,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102334"],"award-info":[{"award-number":["82102334"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073417"],"award-info":[{"award-number":["82073417"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To address current challenges in effectively treating large skin defects caused by trauma in clinical medicine, the fabrication, and evaluation of a novel radially aligned nanofiber scaffold (RAS) with dual growth factor gradients is presented. These aligned nanofibers and the scaffold's spatial design provide many all\u2010around \u201chighways\u201d for cell migration from the edge of the wound to the center area. Besides, the chemotaxis induced by two growth factor gradients further promotes cell migration. Incorporating epidermal growth factor (EGF) aids in the proliferation and differentiation of basal layer cells in the epidermis, augmenting the scaffold's ability to promote epidermal regeneration. Concurrently, the scaffold\u2010bound vascular endothelial growth factor (VEGF) recruits vascular endothelial cells at the wound's center, resulting in angiogenesis and improving blood supply and nutrient delivery, which is critical for granulation tissue regeneration. The RAS+EGF+VEGF group demonstrates superior performance in wound immune regulation, wound closure, hair follicle regeneration, and ECM deposition and remodeling compared to other groups. This study highlights the promising potential of hierarchically assembled nanofiber scaffolds with dual growth factor gradients for wound repair and tissue regeneration applications.<\/jats:p>","DOI":"10.1002\/advs.202309993","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T21:30:20Z","timestamp":1707341420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Hierarchically Assembled Nanofiber Scaffolds with Dual Growth Factor Gradients Promote Skin Wound Healing Through Rapid Cell Recruitment"],"prefix":"10.1002","volume":"11","author":[{"given":"Ruyi","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology School of Basic Medical Sciences Southern Medical University  Guangzhou 510515 China"},{"name":"National Medical Products Administration (NMPA) and Guangdong Medical Products Administration (GDMPA) Key Laboratory for Safety Evaluation of Cosmetics  Guangzhou 510515 China"},{"name":"Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang 325000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang 325000 China"},{"name":"Department of Burn and Plastic Surgery Affiliated Hospital of Nantong University  Nantong 226001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang 325000 China"},{"name":"Department of Burn and Plastic Surgery Affiliated Hospital of Nantong University  Nantong 226001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang 325000 China"},{"name":"Department of Burn and Plastic Surgery Affiliated Hospital of Nantong University  Nantong 226001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Surgery \u2013 Transplant Holland Regenerative Medicine Program University of Nebraska Medical Center  Omaha Nebraska 68105 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery Affiliated Hospital of Nantong University  Nantong 226001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7905-3268","authenticated-orcid":false,"given":"Shixuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology School of Basic Medical Sciences Southern Medical University  Guangzhou 510515 China"},{"name":"National Medical Products Administration (NMPA) and Guangdong Medical Products Administration (GDMPA) Key Laboratory for Safety Evaluation of Cosmetics  Guangzhou 510515 China"},{"name":"Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang 325000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology School of Basic Medical Sciences Southern Medical University  Guangzhou 510515 China"},{"name":"National Medical Products Administration (NMPA) and Guangdong Medical Products Administration (GDMPA) Key Laboratory for Safety Evaluation of Cosmetics  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1794-y"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00377-3"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2015.0640"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-020-0130-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5314\/wjd.v6.i1.1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.03.012"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118924"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c04206"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.03.035"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.03.091"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-020-0209-x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3980"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3937"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b00217"},{"key":"e_1_2_9_11_2","first-page":"31","volume":"7","author":"Chen S.","year":"2021","journal-title":"Sci. Adv."},{"key":"e_1_2_9_11_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.06.031"},{"key":"e_1_2_9_11_4","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.1c00344"},{"key":"e_1_2_9_11_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.12.018"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-019-09492-1"},{"key":"e_1_2_9_13_1","author":"James B.","year":"2015","journal-title":"Development (Cambridge, England)"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-018-0044-5"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.689328"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.004077"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129452"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316851"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.136861"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxaa008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13024"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53165"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.3040"},{"key":"e_1_2_9_19_3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.654749"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14923"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4342"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02346"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.08.005"}],"updated-by":[{"DOI":"10.1002\/advs.202501010","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T00:00:00Z","timestamp":1738972800000}}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202309993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T19:21:21Z","timestamp":1759778481000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202309993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,7]]},"references-count":35,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/advs.202309993"],"URL":"https:\/\/doi.org\/10.1002\/advs.202309993","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1002\/advs.202501010","asserted-by":"object"}]},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,7]]},"assertion":[{"value":"2023-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2309993"}}