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DSGM reportedly impairs the fertility of male mice; however, the regulatory mechanism is unclear. Exosomes are molecular mediators of intercellular communication, but the regulation of spermatogenesis by non\u2010reproductive tissue\u2010originated exosomes remains unknown. The present study shows that DSGM altered the miRNA expression profile of mouse circulating exosomes and impaired spermatogenesis. Moreover, the single\u2010cell sequencing results indicate that circulating exosomes from mice with DSGM impaired spermatogenesis, while circulating exosomes from wild mice improved spermatogenesis by promoting meiosis. Further study demonstrates that DSGM leads to abnormal upregulation of miR\u2010211\u20105p in gut\u2010derived circulating exosomes, which inhibited the expression of meiosis\u2010specific with coiled\u2010coil domain (Meioc) in the testes and impaired spermatogenesis by disturbing meiosis process. In summary, this study defines the important role of gut\u2010derived exosomes in connecting the \u201cgut\u2010testis\u201d axis.<\/jats:p>","DOI":"10.1002\/advs.202310110","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T09:34:54Z","timestamp":1711359294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Gut\u2010Derived Exosomes Mediate the Microbiota Dysbiosis\u2010Induced Spermatogenesis Impairment by Targeting Meioc in Mice"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0519-7765","authenticated-orcid":false,"given":"Tong","family":"Chen","sequence":"first","affiliation":[{"name":"College of Animal Sciences Jilin University  5333 Xian Road Changchun Jilin 130062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Sciences 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