{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:21:28Z","timestamp":1791912088247,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T00:00:00Z","timestamp":1709942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M712472"],"award-info":[{"award-number":["2022M712472"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Intrinsic immunosuppressive tumor microenvironment (ITM) and insufficient tumor infiltration of T cells severely impede the progress of glioblastoma (GBM) immunotherapy. In this study, it is identify that inhibiting the expression of glucose transporter 1 (GLUT1) can facilitate the prevention of lactate excretion from tumor glycolysis, which significantly alleviates the lactate\u2010driven ITM by reducing immunosuppressive tumor\u2010associated macrophages (TAMs) and regulatory T cells (Tregs). Simultaneously, the findings show that the generated inflammatory cytokine IFN\u2010\u03b3 during immune activation aggravates the immune escape by upregulating immune checkpoint programmed death\u2010ligand 1 (PD\u2010L1) in tumor cells and TAMs. Therefore, an injectable thermogel loaded with a GLUT1 inhibitor BAY\u2010876 and a PD\u20101\/PD\u2010L1 blocker BMS\u20101 (Gel@B\u2010B) for dual\u2010regulation of metabolism and immunity of GBM is developed. Consequently, in situ injection of Gel@B\u2010B significantly delays tumor growth and prolongs the survival of the orthotopic GBM mouse model. By actively exposing tumor antigens to antigen\u2010presenting cells, the GBM vaccine combined with Gel@B\u2010B is found to significantly increase the fraction of effector T cells (Th1\/CTLs) in the tumor microenvironment, thereby remarkably mitigating tumor recurrence long\u2010term. This study may provide a promising strategy for GBM immunotherapy.<\/jats:p>","DOI":"10.1002\/advs.202310163","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T14:39:52Z","timestamp":1709995192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Metabolism\/Immunity Dual\u2010Regulation Thermogels Potentiating Immunotherapy of Glioblastoma Through Lactate\u2010Excretion Inhibition and PD\u20101\/PD\u2010L1 Blockade"],"prefix":"10.1002","volume":"11","author":[{"given":"Tianliang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology Zhongnan Hospital of Wuhan University  169 Donghu Road Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Zhongnan Hospital of Wuhan University  169 Donghu Road Wuhan 430071 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