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Current clinical treatments are limited in their ability to control bacteria and infection, which is unfavorable for new bone formation and calls for a new type of material with excellent osteogenic and antibacterial properties. Here a multifunctional scaffold is synthesized that mimics natural bone nanostructures by incorporating silver nanowires\u00a0into a hierarchical, intrafibrillar mineralized collagen matrix (IMC\/AgNWs), to achieve the therapeutic goals of inhibiting bacterial activity and promoting infectious alveolar bone augmentation in rats and beagle dogs. An appropriate concentration of 0.5\u00a0mg\u00a0mL<jats:sup>\u22121<\/jats:sup> AgNWs is selected to balance biocompatibility and antibacterial properties. The achieved IMC\/AgNWs exhibit a broad spectrum of antimicrobial properties against Gram\u2010negative <jats:italic>Porphyromonas gingivalis<\/jats:italic> and Gram\u2010positive <jats:italic>Streptococcus mutans<\/jats:italic>. When the IMC\/AgNWs are cocultured with periodontal ligament stem cells, it possesses excellent osteoinductive activities under both non\u2010inflammatory and inflammatory conditions. By constructing a rat mandibular infected periodontal defect model, the IMC\/AgNWs achieve a near\u2010complete healing through the canonical BMP\/Smad signaling. Moreover, the IMC\/AgNWs enhance vertical bone height and osseointegration in peri\u2010implantitis in beagle dogs, indicating the clinical translational potential of IMC\/AgNWs for infectious vertical bone augmentation.<\/jats:p>","DOI":"10.1002\/advs.202310292","type":"journal-article","created":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T05:49:16Z","timestamp":1714888156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A Biomimetic Multifunctional Scaffold for Infectious Vertical Bone Augmentation"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0701-3771","authenticated-orcid":false,"given":"Yifan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oral Implantology National Center for Stomatology National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology Translational 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