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However, precise modulation of dynamic variations in microenvironmental inflammation post\u2010implantation remains challenging. In this study, the traditional \u03b2\u2010tricalcium phosphate\u2010based scaffold is remodeled via ultrathin MXene\u2010Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    decoration and Zn\n                    <jats:sup>2+<\/jats:sup>\n                    \/Sr\n                    <jats:sup>2+<\/jats:sup>\n                    ion\u2010substitution, endowing the scaffold with excellent reactive oxygen species\u2010scavenging ability, near\u2010infrared responsivity, and enhanced mechanical properties. The induction of mild hyperthermia around the implant via periodic near\u2010infrared irradiation facilitates spatiotemporal regulation of inflammatory cytokines secreted by a spectrum of macrophage phenotypes. The process initially amplifies the pro\u2010inflammatory response, then accelerates M1\u2010to\u2010M2 macrophage polarization transition, yielding a satisfactory pattern of osteo\u2010immunomodulation during the natural bone healing process. Later, sustained release of Zn\n                    <jats:sup>2+<\/jats:sup>\n                    \/Sr\n                    <jats:sup>2+<\/jats:sup>\n                    ions with gradual degradation of the 3D scaffold maintains the favorable reparative M2\u2010dominated immunological microenvironment that supports new bone mineralization. Precise temporal immunoregulation of the bone healing process by the intelligent 3D scaffold enhances bone regeneration in a rat cranial defect model. This strategy paves the way for the application of \u03b2\u2010tricalcium phosphate\u2010based materials to guide the dynamic inflammatory and bone tissue responses toward a favorable outcome, making clinical treatment more predictable and durable. The findings also demonstrate that near\u2010infrared irradiation\u2010derived mild hyperthermia is a promising method of immunomodulation.\n                  <\/jats:p>","DOI":"10.1002\/advs.202400229","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T03:12:03Z","timestamp":1720408323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Ti\n                    <sub>3<\/sub>\n                    C\n                    <sub>2<\/sub>\n                    T\n                    <sub>x<\/sub>\n                    MXene\u2010Decorated 3D\u2010Printed Ceramic Scaffolds for Enhancing Osteogenesis by Spatiotemporally Orchestrating Inflammatory and Bone Repair Responses"],"prefix":"10.1002","volume":"11","author":[{"given":"Benzhao","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Stomatology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong 250021 P. 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