{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:44:40Z","timestamp":1789785880364,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018558","name":"Shanghai Shuguang Program","doi-asserted-by":"publisher","award":["21SG39"],"award-info":[{"award-number":["21SG39"]}],"id":[{"id":"10.13039\/501100018558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Photosynthesis, essential for life on earth, sustains diverse processes by providing nutrition in plants and microorganisms. Especially, photosynthesis is increasingly applied in disease treatments, but its efficacy is substantially limited by the well\u2010known low penetration depth of external light. Here, ultrasound\u2010mediated photosynthesis is reported for enhanced sonodynamic tumor therapy using organic sonoafterglow (ultrasound\u2010induced afterglow) nanoparticles combined with cyanobacteria, demonstrating the proof\u2010of\u2010concept sonosynthesis (sonoafterglow\u2010induced photosynthesis) in cancer therapy. Chlorin e6, a typical small\u2010molecule chlorine, is formulated into nanoparticles to stimulate cyanobacteria for sonosynthesis, which serves three roles, i.e., overcoming the tissue\u2010penetration limitations of external light sources, reducing hypoxia, and acting as a sonosensitizer for in vivo tumor suppression. Furthermore, sonosynthetic oxygenation suppresses the expression of hypoxia\u2010inducible factor 1\u03b1, leading to reduced stability of downstream SLC7A11 mRNA, which results in glutathione depletion and inactivation of glutathione peroxidase 4, thereby inducing ferroptosis of cancer cells. This study not only broadens the scope of microbial nanomedicine but also offers a distinct direction for sonosynthesis.<\/jats:p>","DOI":"10.1002\/advs.202400251","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:43:34Z","timestamp":1718239414000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Sonosynthetic Cyanobacteria Oxygenation for Self\u2010Enhanced Tumor\u2010Specific Treatment"],"prefix":"10.1002","volume":"11","author":[{"given":"Zhenyu","family":"Yang","sequence":"first","affiliation":[{"name":"Materdicine Lab School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Shen","sequence":"additional","affiliation":[{"name":"Materdicine Lab School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Jin","sequence":"additional","affiliation":[{"name":"Materdicine Lab School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Materdicine Lab School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"},{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"},{"name":"School of Medicine Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200080 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyao","family":"Wu","sequence":"additional","affiliation":[{"name":"Materdicine Lab School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehong","family":"Yu","sequence":"additional","affiliation":[{"name":"Materdicine Lab School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Materdicine Lab School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Feng","sequence":"additional","affiliation":[{"name":"Materdicine Lab School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"},{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"},{"name":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health) Wenzhou Institute of Shanghai University  Wenzhou Zhejiang 325088 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-3325","authenticated-orcid":false,"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Materdicine Lab School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"},{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"},{"name":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health) Wenzhou Institute of Shanghai University  Wenzhou Zhejiang 325088 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1525"},{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay2058"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43016-023-00858-y"},{"key":"e_1_2_7_2_2","first-page":"851","volume":"377","author":"De Souza A. P.","year":"2022","journal-title":"Sci. Adv."},{"key":"e_1_2_7_2_3","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12699"},{"key":"e_1_2_7_2_4","doi-asserted-by":"publisher","DOI":"10.1038\/nphoton.2012.175"},{"key":"e_1_2_7_2_5","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh8043"},{"key":"e_1_2_7_2_6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.01.052"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-019-0149-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05499-y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-018-0251-7"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1257594"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202305866"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba5996"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32066-w"},{"key":"e_1_2_7_7_3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201910176"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg3478"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba4311"},{"key":"e_1_2_7_8_3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202201875"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40265-2"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-021-00350-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1603078"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-016-0008"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba3009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4344"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210216"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30713-w"},{"key":"e_1_2_7_13_3","first-page":"679","volume":"359","author":"Chen S.","year":"2018","journal-title":"Sci. Adv."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32054-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm7077"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41389-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-022-01468-y"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38554-x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00699"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00922-3"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00978-z"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0167-3"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31551-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.003"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112945"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113110"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-020-00789-5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.0c00029"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c10168"},{"key":"e_1_2_7_25_3","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)00952-8"},{"key":"e_1_2_7_25_4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00649"},{"key":"e_1_2_7_25_5","doi-asserted-by":"publisher","DOI":"10.1007\/s10570-020-03351-y"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c09473"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202400251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:39:47Z","timestamp":1759775987000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202400251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,12]]},"references-count":48,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/advs.202400251"],"URL":"https:\/\/doi.org\/10.1002\/advs.202400251","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,12]]},"assertion":[{"value":"2024-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400251"}}