{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:54:21Z","timestamp":1792598061631,"version":"4.5.0"},"reference-count":65,"publisher":"Wiley","issue":"44","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073020"],"award-info":[{"award-number":["82073020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lymph node metastasis, the initial step in distant metastasis, represents a primary contributor to mortality in patients diagnosed with oral squamous cell carcinoma (OSCC). However, the underlying mechanisms of lymph node metastasis in OSCC remain incompletely understood. Here, the transcriptomes of 56\u00a0383 single cells derived from paired tissues of six OSCC patients are analyzed. This study founds that CXCR4\n                    <jats:sup>+<\/jats:sup>\n                    epithelial cells, identified as highly malignant disseminated tumor cells (DTCs), exhibited a propensity for lymph node metastasis. Importantly, a distinct subset of tumor\u2010associated macrophages (TAMs) characterized by exclusive expression of phosphoprotein 1 (SPP1) is discovered. These TAMs may remodel the metastatic lymph node microenvironment by potentially activating fibroblasts and promoting T cell exhaustion through SPP1\u2010CD44 and CD155\u2010CD226 ligand\u2010receptor interactions, thereby facilitating colonization and proliferation of disseminated tumor cells. The research advanced the mechanistic understanding of metastatic tumor microenvironment (TME) and provided a foundation for the development of personalized treatments for OSCC patients with metastasis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202400524","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T16:44:21Z","timestamp":1725554661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["SPP1\n                    <sup>+<\/sup>\n                    TAM Regulates the Metastatic Colonization of CXCR4\n                    <sup>+<\/sup>\n                    Metastasis\u2010Associated Tumor Cells by Remodeling the Lymph Node Microenvironment"],"prefix":"10.1002","volume":"11","author":[{"given":"Liang","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Dermatology Hunan Engineering Research Center of Skin Health and Disease Hunan Key Laboratory of Skin 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Center of Oral and Maxillofacail Tumor Xiangya Hospital Central South University  Changsha Hunan 410008 China"},{"name":"Insititute of Oral Cancer and Precancerous Lesions Central South University  Changsha Hunan 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Research Center (CRC) Medical Pathology Center (MPC) Cancer Early Detection and Treatment Center (CEDTC) Chongqing University Three Gorges Hospital Chongqing University  Chongqing 404100 China"},{"name":"Translational Medicine Research Center (TMRC) School of Medicine Chongqing University  Chongqing 404100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyao","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hunan Engineering Research Center of Skin Health and Disease Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital Central South University  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Oral and Maxillofacial Surgery Center of Stomatology Xiangya Hospital Central South University  Changsha Hunan 410008 China"},{"name":"Research Center of Oral and Maxillofacail Tumor Xiangya Hospital Central South University  Changsha Hunan 410008 China"},{"name":"Insititute of Oral Cancer and Precancerous Lesions Central South University  Changsha Hunan 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6964-7131","authenticated-orcid":false,"given":"Mingzhu","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hunan Engineering Research Center of Skin Health and Disease Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya Hospital Central South University  Changsha Hunan 410008 China"},{"name":"Clinical Research Center (CRC) Medical Pathology Center (MPC) Cancer Early Detection and Treatment Center (CEDTC) Chongqing University Three Gorges Hospital Chongqing University  Chongqing 404100 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