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Outer membrane vesicles (OMVs) as a pathogenic entity have recently attracted great attention as messenger bridges between bacteria and host tissues. Herein, the novel role of OMVs derived from\n                    <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                    in the occurrence of periodontitis is dissected. In a rat periodontitis model, it is found that OMVs derived from\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    caused deterioration of periodontitis by enhancing inflammation of the periodontium and absorption of alveolar bone, which is almost equivalent to the effect of\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    itself. Furthermore, that OMVs can independently induce periodontitis is shown. The pathogenicity of OMVs is attributed to multiple pathogenic components identified by omics. After entering human periodontal ligament stem cells (hPDLSCs) by endocytosis, OMVs activated NLRP3 inflammasomes and impaired the mineralization of hPDLSCs through NF\u2010\u03baB (p65) signaling, leading to the final injury of the periodontium and damage of alveolar bone in periodontitis. These results provide a new understanding of OMVs derived from pathogens and cues for the prevention of periodontitis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202400882","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T12:09:02Z","timestamp":1730290142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Outer Membrane Vesicles Derived From\n                    <i>Fusobacterium nucleatum<\/i>\n                    Trigger Periodontitis Through Host Overimmunity"],"prefix":"10.1002","volume":"11","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, West China School of Basic Medical Sciences and Forensic Medicine Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; 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