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Here, the authors demonstrate that the ubiquitin ligase seven in absentia1 (SINA1) mammalian BTF2\u2010like transcription factors, Drosophila synapse\u2010associated proteins, and yeast DOS2\u2010like proteins (BSD1) function as a regulatory module to control vegetative growth in tomato via regulation of the production of plant growth hormone gibberellin (GA). SINA1 negatively regulates the protein level of BSD1 through ubiquitin\u2010proteasome\u2010mediated degradation, and the transgenic tomato over\u2010expressing <jats:italic>SINA1<\/jats:italic> (<jats:italic>SINA1\u2010OX<\/jats:italic>) resembles the dwarfism phenotype of the <jats:italic>BSD1<\/jats:italic>\u2010knockout (<jats:italic>BSD1\u2010KO<\/jats:italic>) tomato plant. BSD1 directly activates expression of the <jats:italic>BSD1\u2010<jats:styled-content>r<\/jats:styled-content>egulated <jats:styled-content>g<\/jats:styled-content>ene <jats:styled-content>1<\/jats:styled-content><\/jats:italic> (<jats:italic>BRG1<\/jats:italic>) via binding to a novel core BBS (standing for <jats:styled-content>B<\/jats:styled-content>SD1 <jats:styled-content>b<\/jats:styled-content>inding <jats:styled-content>s<\/jats:styled-content>ite) binding motif in the <jats:italic>BRG1<\/jats:italic> promoter. Knockout of <jats:italic>BRG1<\/jats:italic> (<jats:italic>BRG1\u2010KO<\/jats:italic>) in tomato also results in a dwarfism phenotype, suggesting BRG1 plays a positive role in vegetative growth as BSD1 does. Significantly, GA contents are attenuated in transgenic <jats:italic>SINA1\u2010OX<\/jats:italic>, <jats:italic>BSD1\u2010KO<\/jats:italic>, and <jats:italic>BRG1\u2010KO<\/jats:italic> plants exhibiting dwarfism phenotype and exogenous application of bioactive GA<jats:sub>3<\/jats:sub> restores their vegetative growth. Moreover, BRG1 is required for the expression of multiple GA biosynthesis genes and BSD1 activates three GA biosynthesis genes promoting GA production. Thus, this study suggests that the SINA1\u2010BSD1 module controls vegetative growth via direct and indirect regulation of GA biosynthesis in tomato.<\/jats:p>","DOI":"10.1002\/advs.202400995","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T12:40:40Z","timestamp":1724762440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The SINA1\u2010BSD1 Module Regulates Vegetative Growth Involving Gibberellin Biosynthesis in Tomato"],"prefix":"10.1002","volume":"11","author":[{"given":"Yulin","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Plant Sciences University of Idaho  Moscow ID 83844 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youhong","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences University of Idaho  Moscow ID 83844 USA"},{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei Anhui 230009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences University of Idaho  Moscow ID 83844 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Lu","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary Institute of Biodiversity Science and Institute of Eco\u2011Chongming School of Life Sciences Fudan University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Biology University of Mississippi  Oxford MS 38677 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"Gao","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary Institute of Biodiversity Science and Institute of Eco\u2011Chongming School of Life Sciences Fudan University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cankui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Agronomy Purdue Center for Plant Biology Purdue University  915 Mitch Daniels Blvd West Lafayette IN 47907 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Hefei University of Technology  Hefei Anhui 230009 China"},{"name":"School of Horticulture Anhui Agricultural University  Hefei Anhui 230036 China"},{"name":"Ministry of Education Key Laboratory for Bio\u2010resource and Eco\u2010environment College of Life Science State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University  Chengdu Sichuan 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6044-9465","authenticated-orcid":false,"given":"Fangming","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences University of Idaho  Moscow ID 83844 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