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The disruption or scavenging of NETs using deoxyribonuclease (DNase) or cationic nanoparticles has been limited by liberating trapped bacteria, short half\u2010life, or potential cytotoxicity. In this study, a positive correlation between the NETs level in diabetic wound exudation and the severity of wound inflammation in diabetic patients is established. Novel NETs scavenging bio\u2010based hydrogel microspheres \u2018micro\u2010cage\u2019, termed mPDA\u2010PEI@GelMA, is engineered by integrating methylacrylyl gelatin (GelMA) hydrogel microspheres with cationic polyethyleneimine (PEI)\u2010functionalized mesoporous polydopamine (mPDA). This unique \u2018micro\u2010cage\u2019 construct is designed to non\u2010contact scavenge of NETs between nanoparticles and the diabetic wound surface, minimizing biological toxicity and ensuring high biosafety. NETs are introduced into \u2018micro\u2010cage\u2019 along with wound exudation, and cationic mPDA\u2010PEI immobilizes them inside the \u2018micro\u2010cage\u2019 through a strong binding affinity to the cfDNA web structure. The findings demonstrate that mPDA\u2010PEI@GelMA effectively mitigates pro\u2010inflammatory responses associated with diabetic wounds by scavenging NETs both in vivo and in vitro. This work introduces a novel nanoparticle non\u2010contact NETs scavenging strategy to enhance diabetic wound healing processes, with potential benefits in clinical applications.<\/jats:p>","DOI":"10.1002\/advs.202401195","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T19:39:16Z","timestamp":1712432356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Innovative Bio\u2010based Hydrogel Microspheres Micro\u2010Cage for Neutrophil Extracellular Traps Scavenging in Diabetic Wound Healing"],"prefix":"10.1002","volume":"11","author":[{"given":"Yongqiang","family":"Xiao","sequence":"first","affiliation":[{"name":"ENT Institute Department of Facial Plastic and Reconstructive Surgery Eye &amp; ENT Hospital Fudan University  Shanghai 200031 P. R. 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