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Current techniques that target only a subset of cytokines often fall short due to the intricate nature of redundant and compensatory cytokine networks. A promising solution to this challenge is using cell membrane\u2010coated nanoparticles (CNPs). These nanoparticles replicate the complex interactions between cells and cytokines observed in disease pathology, providing a potential avenue for multiplex cytokine scavenging. While the development of CNPs using experimental animal models has shown great promise, their effectiveness in scavenging multiple cytokines in human diseases has yet to be demonstrated. To bridge this gap, this study selected macrophage membrane\u2010coated CNPs (M\u0424\u2010CNPs) and assessed their ability to scavenge inflammatory cytokines in serum samples from patients with COVID\u201019, sepsis, acute pancreatitis, or type\u20101 diabetes, along with synovial fluid samples from patients with rheumatoid arthritis. The results show that M\u0424\u2010CNPs effectively scavenge critical inflammatory cytokines, including interleukin (IL)\u20106, IL\u20108, interferon (IFN)\u2010\u03b3, and tumor necrosis factor (TNF)\u2010\u03b1, in a dose\u2010dependent manner. Overall, this study demonstrates M\u0424\u2010CNPs as a multiplex cytokine scavenging formulation with promising applications in clinical settings to treat a range of inflammatory disorders.<\/jats:p>","DOI":"10.1002\/advs.202401423","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T06:29:32Z","timestamp":1718605772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Macrophage\u2010Mimicking Cellular Nanoparticles Scavenge Proinflammatory Cytokines in Specimens of Patients with Inflammatory Disorders"],"prefix":"10.1002","volume":"11","author":[{"given":"Zhidong","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Nanoengineering and Chemical Engineering Program University of California San Diego  La Jolla CA 92093 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