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Given the central role of cell\u2010derived nitric oxide (NO) in modulating the endogenous repair of vascular injury, NO\u2010generating proteolipid nanovesicles (PLV\u2010NO) are designed that recapitulate the cell\u2010mimicking functions for vascular repair and replacement. Specifically, the proteolipid nanovesicles (PLV) are versatilely fabricated using membrane proteins derived from different types of cells, followed by the incorporation of NO\u2010generating nanozymes capable of catalyzing endogenous donors to produce NO. Taking two vascular injury models, two types of PLV\u2010NO are tailored to meet the individual requirements of targeted diseases using platelet membrane proteins and endothelial membrane proteins, respectively. The platelet\u2010based PLV\u2010NO (pPLV\u2010NO) demonstrates its efficacy in targeted repair of a vascular endothelium injury model through systemic delivery. On the other hand, the endothelial cell (EC)\u2010based PLV\u2010NO (ePLV\u2010NO) exhibits suppression of thrombosis when modified onto a locally transplanted small\u2010diameter vascular graft (SDVG). The versatile design of PLV\u2010NO may enable a promising therapeutic option for various vascular injury\u2010evoked cardiovascular diseases.<\/jats:p>","DOI":"10.1002\/advs.202401844","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T07:01:46Z","timestamp":1718607706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Versatile Design of NO\u2010Generating Proteolipid Nanovesicles for Alleviating Vascular Injury"],"prefix":"10.1002","volume":"11","author":[{"given":"Yueyue","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory of Bioactive Materials for the Ministry of Education College of Life Sciences Nankai University  Tianjin 300071 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials for the Ministry of Education College of 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