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Herein an osteoimmunity\u2010regulating biopatch capable of promoting stem cell\u2010based therapies for bone regeneration is developed. A totally biodegradable conjugate is first synthesized, which can self\u2010assemble into bioactive nano micelles (PPT NMs). This nanotherapy effectively improves the osteogenesis of periodontal ligament stem cells (PDLSCs) under pathological conditions, by simultaneously regulating IL\u201017 signaling and ferroptosis pathways. Incorporation of PPT NMs into biodegradable electrospun nanofibers affords a bioactive patch, which notably improves bone formation in two rat bone defect models. A Janus bio patch is then engineered by integrating the bioactive patch with a stem cell sheet of PDLSCs. The obtained biopatch shows additionally potentiated bone regeneration capacity, by synergistically regulating osteoimmune microenvironment and facilitating stem cell differentiation. Further surface functionalization of the biopatch with tannic acid considerably increases its adhesion to the bone defect, prolongs local retention, and sustains bioactivities, thereby offering much better repair effects in rats with mandibular or cranial bone defects. Moreover, the engineered bioactive patches display good safety. Besides bone defects, this osteoimmunity\u2010regulating biopatch strategy can be applied to promote stem cell therapies for spinal cord injury, wound healing, and skin burns.<\/jats:p>","DOI":"10.1002\/advs.202401882","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T12:51:05Z","timestamp":1721307065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["An Osteoimmunomodulatory Biopatch Potentiates Stem Cell Therapies for Bone Regeneration by Simultaneously Regulating IL\u201017\/Ferroptosis Signaling Pathways"],"prefix":"10.1002","volume":"11","author":[{"given":"Shan","family":"Liu","sequence":"first","affiliation":[{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Stomatological Hospital of Chongqing Medical University Chongqing Medical University  Chongqing 401147 P. 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