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However, challenges in wound healing and residual tumor metastasis pose significant hurdles, resulting in high recurrence rates in patients. Herein, a bioactive injectable hydrogel (BG\u2010Mn<jats:sup>gel<\/jats:sup>) formed by crosslinking sodium alginate (SA) with manganese\u2010doped bioactive glass (BG\u2010Mn) is developed as a versatile platform for anti\u2010tumor immunotherapy and postoperative wound healing for melanoma. The incorporation of Mn<jats:sup>2+<\/jats:sup> within bioactive glass (BG) can activate the cGAS\u2010STING immune pathway to elicit robust immune response for cancer immunotherapy. Furthermore, doping Mn<jats:sup>2+<\/jats:sup> in BG endows system with excellent photothermal properties, hence facilitating STING activation and reversing the tumor immune\u2010suppressive microenvironment. BG exhibits favorable angiogenic capacity and tissue regenerative potential, and Mn<jats:sup>2+<\/jats:sup> promotes cell migration in vitro. When combining BG\u2010Mn<jats:sup>gel<\/jats:sup> with anti\u2010PD\u20101 antibody (\u03b1\u2010PD\u20101) for the treatment of malignant melanoma, it shows enhanced anti\u2010tumor immune response and long\u2010term immune memory response. Remarkably, BG\u2010Mn<jats:sup>gel<\/jats:sup> can upregulate the expression of genes related to blood vessel formation and promote skin tissue regeneration when treating full\u2010thickness wounds. Overall, BG\u2010Mn<jats:sup>Gel<\/jats:sup> serves as an effective adjuvant therapy to regulate tumor metastasis and wound healing for malignant melanoma.<\/jats:p>","DOI":"10.1002\/advs.202402208","type":"journal-article","created":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T06:15:22Z","timestamp":1714889722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["A Bioactive Injectable Hydrogel Regulates Tumor Metastasis and Wound Healing for Melanoma via NIR\u2010Light Triggered Hyperthermia"],"prefix":"10.1002","volume":"11","author":[{"given":"Xueyi","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing Laboratory of Biomedical Materials College of Life Science and Technology Beijing University of Chemical Technology  Beijing 100029 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