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However, the specific mechanism by which OSA induces NAFLD remains unclear. Therefore, effective interventions are lacking. This study aims to investigate the role and mechanism of ferroptosis in OSA\u2010related NAFLD using clinical data analyses, cell\u2010based molecular experiments, and animal experiments. Indicators of liver function, lipid accumulation, and ferroptosis are also examined. RNA\u2010seq, qPCR, western blotting, gene intervention, and E3 ligase prediction using UbiBrowser and co\u2010IP are used to explore the potential underlying mechanisms. The results show that ferroptosis increases in the liver tissues of patients with OSA. Chronic IH promotes NAFLD progression in mice and is alleviated by a ferroptosis inhibitor Fer\u20101. The increased secretion of IL6 by macrophages can promote the expression of MARCH3 in hepatocytes under intermittent conditions, and subsequently promote the ubiquitination and degradation of GPX4 to regulate ferroptosis and lipid accumulation in hepatocytes. Hence, targeted inhibition of MARCH3 may alleviate IH\u2010induced ferroptosis and lipid accumulation in liver tissues and inhibit the progression of NAFLD.<\/jats:p>","DOI":"10.1002\/advs.202402241","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T07:14:58Z","timestamp":1725434098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["IL6 Derived from Macrophages under Intermittent Hypoxia Exacerbates NAFLD by Promoting Ferroptosis via MARCH3\u2010Led Ubiquitylation of GPX4"],"prefix":"10.1002","volume":"11","author":[{"given":"Weisong","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Zhongnan Hospital of Wuhan University  Wuhan 430071 China"},{"name":"Sleep Medicine Center Zhongnan Hospital of Wuhan University  Wuhan 430071 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