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This methodology addresses the limitations of traditional alkylation methods, such as the need for strong metallic bases, regioselectivity issues, and the risk of over alkylation, by providing a high reactivity and chemoselectivity without the necessity for pre\u2010functionalized substrates. The dual catalytic strategy enables the direct functionalization of C(sp<jats:sup>3<\/jats:sup>)\u2500H bonds, demonstrating remarkable selectivity in the presence of conventional C(sp<jats:sup>3<\/jats:sup>)\u2500H bonds that are adjacent to heteroatoms or <jats:italic>\u03c0<\/jats:italic> systems, which are typically susceptible to single\u2010electron transfer processes. The findings contribute to the advancement of alkylation techniques, offering a practical and efficient route for the construction of C(sp<jats:sup>3<\/jats:sup>)\u2500C(sp<jats:sup>3<\/jats:sup>) bonds, and paving the way for further developments in the synthesis of complex organic molecules.<\/jats:p>","DOI":"10.1002\/advs.202402255","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T14:54:25Z","timestamp":1718636065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synergistic Copper\u2010Aminocatalysis for Direct Tertiary \u03b1\u2010Alkylation of Ketones with Electron\u2010Deficient Alkanes"],"prefix":"10.1002","volume":"11","author":[{"given":"Qi\u2010Chao","family":"Shan","sequence":"first","affiliation":[{"name":"Institute of Advanced Synthesis School of Chemistry and Molecular Engineering Nanjing Tech University  30 South Puzhu Road Nanjing 211816 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