{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:27:35Z","timestamp":1788488855745,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"25","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12174074"],"award-info":[{"award-number":["12174074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2322018"],"award-info":[{"award-number":["T2322018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171391"],"award-info":[{"award-number":["32171391"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018558","name":"Shanghai Shuguang Program","doi-asserted-by":"publisher","award":["21SG39"],"award-info":[{"award-number":["21SG39"]}],"id":[{"id":"10.13039\/501100018558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["22QA1403600"],"award-info":[{"award-number":["22QA1403600"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Photocatalytic carbon dioxide (CO<jats:sub>2<\/jats:sub>) reduction is an effective method for in vivo carbon monoxide (CO) generation for antibacterial use. However, the available strategies mainly focus on utilizing visible\u2010light\u2010responsive photocatalysts to achieve CO generation. The limited penetration capability of visible light hinders CO generation in deep\u2010seated tissues. Herein, a photothermal CO<jats:sub>2<\/jats:sub> catalyst (abbreviated as NNBCs) to achieve an efficient hyperthermic effect and in situ CO generation is rationally developed, to simultaneously suppress bacterial proliferation and relieve inflammatory responses. The NNBCs are modified with a special polyethylene glycol and further embellished by bicarbonate (BC) decoration via ferric ion\u2010mediated coordination. Upon exposure to 1064\u00a0nm laser irradiation, the NNBCs facilitated efficient photothermal conversion and in situ CO generation through photothermal CO<jats:sub>2<\/jats:sub> catalysis. Specifically, the photothermal effect accelerated the decomposition of BC to produce CO<jats:sub>2<\/jats:sub> for photothermal catalytic CO production. Benefiting from the hyperthermic effect and in situ CO production, in vivo assessments using an osteomyelitis model confirmed that NNBCs can simultaneously inhibit bacterial proliferation and attenuate the photothermal effect\u2010associated pro\u2010inflammatory response. This study represents the first attempt to develop high\u2010performance photothermal CO<jats:sub>2<\/jats:sub> nanocatalysts to achieve in situ CO generation for the concurrent inhibition of bacterial growth and attenuation of inflammatory responses.<\/jats:p>","DOI":"10.1002\/advs.202402256","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:39:33Z","timestamp":1713832773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Engineering Photothermal Catalytic CO<sub>2<\/sub> Nanoreactor for Osteomyelitis Treatment by In Situ CO Generation"],"prefix":"10.1002","volume":"11","author":[{"given":"Fan","family":"Zhuang","sequence":"first","affiliation":[{"name":"Department of Ultrasound Zhongshan Hospital Fudan University and Shanghai Institute of Medical Imaging  Shanghai 200032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxia","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Zhongshan Hospital Fudan University and Shanghai Institute of Medical Imaging  Shanghai 200032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijing","family":"Xiang","sequence":"additional","affiliation":[{"name":"Materdicine Lab School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuixian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Zhongshan Hospital Fudan University and Shanghai Institute of Medical Imaging  Shanghai 200032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beilei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Zhongshan Hospital Fudan University and Shanghai Institute of Medical Imaging  Shanghai 200032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Zhongshan Hospital Fudan University and Shanghai Institute of Medical Imaging  Shanghai 200032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Zhongshan Hospital Fudan University and Shanghai Institute of Medical Imaging  Shanghai 200032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-3325","authenticated-orcid":false,"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Materdicine Lab School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"},{"name":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine Vision and Brain Health) Wenzhou Institute of Shanghai University  Wenzhou Zhejiang 325088 P. R. China"},{"name":"Shanghai Institute of Materdicine  Shanghai 200051 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beijian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Zhongshan Hospital Fudan University and Shanghai Institute of Medical Imaging  Shanghai 200032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3228"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0055-2"},{"key":"e_1_2_8_1_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202107155"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202104024"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202112782"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.1"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs15317c"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00033"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw7515"},{"key":"e_1_2_8_4_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05918-8"},{"key":"e_1_2_8_4_4","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202212162"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b00345"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121875"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-022-01351-w"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202106773"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c09025"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202207213"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201311225"},{"key":"e_1_2_8_9_3","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202302568"},{"key":"e_1_2_8_9_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16336-z"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201502762"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b05858"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201908486"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b06394"},{"key":"e_1_2_8_11_3","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00664E"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b07818"},{"key":"e_1_2_8_12_2","first-page":"2223","volume":"13","author":"Xiang H.","year":"2019","journal-title":"ACS Nano"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c08773"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-018-0031-9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201606643"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c00990"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.9b01342"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c08045"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn1701"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201204683"},{"key":"e_1_2_8_18_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21047-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b00135"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC00135J"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31500-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202207961"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202204065"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b07492"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201308899"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c03422"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0158-z"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.09.012"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202402256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T01:19:28Z","timestamp":1759799968000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202402256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":47,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/advs.202402256"],"URL":"https:\/\/doi.org\/10.1002\/advs.202402256","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,22]]},"assertion":[{"value":"2024-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2402256"}}