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Exaggerated inflammatory immune response and excessive oxidative stress are key pathological features aggravating myocardium damage. Herein, catalytic immunomodulatory nanocomplexes as anti\u2010AMI therapeutics to resolve reactive oxygen species (ROS)\u2010proinflammatory neutrophils\u2010specific\u2010inflammation is engineered. The nanocomplexes contain lyophilic S100A8\/9 inhibitor ABR2575 in the core of nanoemulsions, which effectively disrupts the neutrophils\u2010S100A8\/A9\u2010inflammation signaling pathway in the AMI microenvironment. Additionally, ROS scavenger ultrasmall Cu\n                    <jats:sub>x<\/jats:sub>\n                    O nanoparticles are incorporated into the nanoemulsions via coordinating with SH groups of poly(ethylene glycol) (PEG)\u2010conjugated lipids, which mimic multiple enzymes, dramatically alleviating the oxidative stress damage to myocardial tissue. This combination strategy significantly suppresses the infiltration of pro\u2010inflammatory monocytes, macrophages, and neutrophils, as well as the secretion of inflammatory cytokines. Additionally, it potentially triggers cardiac Tert activation, which promotes myocardial function and decreases infarction size in preclinical murine AMI models. This approach offers a new nanomedicine for treating AMI, resulting in a dramatically enhanced therapeutic outcome.\n                  <\/jats:p>","DOI":"10.1002\/advs.202402267","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T03:51:12Z","timestamp":1721879472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Immuno\u2010Nanocomplexes Target Heterogenous Network of Inflammation and Immunity in Myocardial Infarction"],"prefix":"10.1002","volume":"11","author":[{"given":"Fan","family":"Su","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine Shanghai Chest Hospital, Shanghai Jiao Tong University  Shanghai 200030 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifan","family":"Ye","sequence":"additional","affiliation":[{"name":"Materdicine Lab, School of Life Sciences Shanghai University  Shanghai 200444 P. R. 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