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Despite considerable research advances, the development of standard therapies, supportive care, and prognosis for the majority of AML and ALL patients remains poor and the development of new effective therapy is urgently needed. Here, it is reported that activation of thermogenic adipose tissues (TATs) by cold exposure or \u03b23\u2010adrenergic receptor agonists markedly alleviated the development and progression of AML and ALL in mouse leukemia models. TAT activation (TATA) monotherapy substantially reduces leukemic cells in bone marrow and peripheral blood, and suppresses leukemic cell invasion, including hepatomegaly and splenomegaly. Notably, TATA therapy prolongs the survivals of AML\u2010 and ALL\u2010bearing mice. Surgical removal of thermogenic brown adipose tissue (BAT) or genetic deletion of uncoupling protein 1 (UCP1) largely abolishes the TATA\u2010mediated anti\u2010leukemia effects. Metabolomic pathway analysis demonstrates that glycolytic metabolism, which is essential for anabolic leukemic cell growth, is severely impaired in TATA\u2010treated leukemic cells. Moreover, a combination of TATA therapy with chemotherapy produces enhanced anti\u2010leukemic effects and reduces chemotoxicity. These data provide a new TATA\u2010based therapeutic paradigm for the effective treatment of AML, ALL, and likely other types of hematological malignancies.<\/jats:p>","DOI":"10.1002\/advs.202402332","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T03:46:40Z","timestamp":1721879200000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effective Prevention and Treatment of Acute Leukemias in Mice by Activation of Thermogenic Adipose Tissues"],"prefix":"10.1002","volume":"11","author":[{"given":"Ruibo","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cellular and Genetic Medicine School of Basic Medical Sciences Fudan University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianran","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology &amp; 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