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Therefore, identifying efficacious interventions to enhance liver regeneration is pivotal for optimizing clinical outcomes. Recent studies have demonstrated that vagotomy exerts an inhibitory effect on liver regeneration following partial hepatectomy, thereby substantiating the pivotal role played by the vagus nerve in the process of liver regeneration. In recent years, electroacupuncture (EA) has emerged as a non\u2010invasive technique for stimulating the vagus nerve. However, EA on hepatic regeneration remains uncertain. In this study, a 70% partial hepatectomy (PH) mouse model is utilized to investigate the effects of EA on acute liver regeneration and elucidate its underlying molecular mechanisms. It is observed that EA at ST36 acutely activated cholinergic neurons in the dorsal motor nucleus of the vagus nerve (DMV), resulting in increased release of acetylcholine from hepatic vagal nerve endings and subsequent activation of IL\u20106 signaling in liver macrophages. Ultimately, these events promoted hepatocyte proliferation and facilitated liver regeneration. These findings provide insights into the fundamental brain\u2010liver axis mechanism through which EA promotes liver regeneration, offering a novel therapeutic approach for post\u2010hepatectomy liver regeneration disorders.<\/jats:p>","DOI":"10.1002\/advs.202402856","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T04:10:53Z","timestamp":1719288653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Electroacupuncture Promotes Liver Regeneration by Activating DMV Acetylcholinergic Neurons\u2010Vagus\u2010Macrophage Axis in 70% Partial Hepatectomy of Mice"],"prefix":"10.1002","volume":"11","author":[{"given":"Liu","family":"Yang","sequence":"first","affiliation":[{"name":"Central Laboratory Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai 201203 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