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Psychomotor retardation may either be related to a motor source like the motor cortex or, alternatively, to a psychomotor source with neural changes outside motor regions, like input regions such as visual cortex. These two alternative hypotheses in main (<jats:italic>n<\/jats:italic> = 41) and replication (<jats:italic>n<\/jats:italic> = 18) MDD samples using 7 Tesla MRI are investigated. Analyzing both global and local connectivity in primary motor cortex (BA4), motor network and middle temporal visual cortex complex (MT+), the main findings in MDD are: 1) Reduced local and global synchronization and increased local\u2010to\u2010global output in motor regions, which do not correlate with psychomotor retardation, though. 2) Reduced local\u2010to\u2010local BA4 \u2013 MT+ functional connectivity (FC) which correlates with psychomotor retardation. 3) Reduced global synchronization and increased local\u2010to\u2010global output in MT+ which relate to psychomotor retardation. 4) Reduced variability in the psychophysical measures of MT+ based motion perception which relates to psychomotor retardation. Together, it is shown that visual cortex MT+ and its relation to motor cortex play a key role in mediating psychomotor retardation. This supports psychomotor over motor hypothesis about the neural source of psychomotor retardation in MDD.<\/jats:p>","DOI":"10.1002\/advs.202403063","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T08:28:57Z","timestamp":1724920137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Motor versus Psychomotor? 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