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To address this issue, this study prepared a chemical\/physical duel\u2010network PEG\u2010CMCS\/AG\/MXene hydrogel composed by chemical disulfide crosslinked network of four\u2010arm polyethylene glycol\/carboxymethyl chitosan (4\u2010Arm\u2010PEG\u2010SH\/CMCS), and the physical network of hydrogen bond of agar (AG). Under near\u2010infrared light (NIR) irradiation, the PEG\u2010CMCS\/AG\/MXene hydrogel undergoes photothermal heating due to integrate of MXene, which destructs the hydrogen bond network and allows the removal of exudate through a mechanism mimicking the sweat gland\u2010like effect of skin pores. The photothermal heating effect also enables the antimicrobial activity to prevent wound infections. The excellent electrical conductivity of PEG\u2010CMCS\/AG\/MXene can promote cell proliferation under the external electrical stimulation (ES) in vitro. The animal experiments of full\u2010thickness skin defect model further demonstrate its ability to accelerate wound healing. The conversion between thioester and thiol achieved with L\u2010cysteine methyl ester hydrochloride (L\u2010CME) can provides the on\u2010demand dissolution of the dressing in situ. This study holds promises to provide a novel solution to the issue of fluid accumulations under hydrogel dressings and offers new approaches to alleviating or avoiding the significant secondary injuries caused by frequent dressing changes.<\/jats:p>","DOI":"10.1002\/advs.202403362","type":"journal-article","created":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T18:50:47Z","timestamp":1722192647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Construction and Performance Study of a Dual\u2010Network Hydrogel Dressing Mimicking Skin Pore Drainage for Photothermal Exudate Removal and On\u2010Demand Dissolution"],"prefix":"10.1002","volume":"11","author":[{"given":"Xiaoxiao","family":"Ma","sequence":"first","affiliation":[{"name":"School of Medical Technology Beijing Institute of Technology  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhi","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Medical Technology Beijing Institute of Technology  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Medical Technology Beijing Institute of Technology  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Polymer Science and Engineering Zhejiang University  Zhejiang 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Beijing Institute of Technology  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medical Technology Beijing Institute of Technology  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medical Technology Beijing Institute of Technology  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Feng","sequence":"additional","affiliation":[{"name":"Plastic Surgery Hospital of Peking Union Medical College and Chinese Academy of Medical Sciences  Beijing 100144 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3773-4548","authenticated-orcid":false,"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medical Technology Beijing Institute of Technology  Beijing 100081 China"},{"name":"School of Materials Science and Engineering Beijing Institute of Technology  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,28]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202208395"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206771"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b12523"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2019.04.001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.07.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202101131"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100477"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301765"},{"key":"e_1_2_9_10_1","first-page":"429","author":"Li Y.","year":"2022","journal-title":"Chem. 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