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However, the mechanisms by which the innate immune system is instigated are poorly defined in colorectal cancer (CRC). Here, a population of CD16\n                    <jats:sup>+<\/jats:sup>\n                    neutrophils that specifically accumulate in CRC tumor tissues by imaging mass cytometry (IMC), immune fluorescence, and flow cytometry, which demonstrated pro\u2010tumor activity by disturbing natural killer (NK) cells are identified. It is found that these CD16\n                    <jats:sup>+<\/jats:sup>\n                    neutrophils possess abnormal cholesterol accumulation due to activation of the CD16\/TAK1\/NF\u2010\u03baB axis, which upregulates scavenger receptors for cholesterol intake including CD36 and LRP1. Consequently, these region\u2010specific CD16\n                    <jats:sup>+<\/jats:sup>\n                    neutrophils not only competitively inhibit cholesterol intake of NK cells, which interrupts NK lipid raft formation and blocks their antitumor signaling but also release neutrophil extracellular traps (NETs) to induce the death of NK cells. Furthermore, CD16\u2010knockout reverses the pro\u2010tumor activity of neutrophils and restored NK cell cytotoxicity. Collectively, the findings suggest that CRC region\u2010specific CD16\n                    <jats:sup>+<\/jats:sup>\n                    neutrophils can be a diagnostic marker and potential therapeutic target for CRC.\n                  <\/jats:p>","DOI":"10.1002\/advs.202403414","type":"journal-article","created":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T00:40:09Z","timestamp":1716597609000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Region\u2010Specific CD16\n                    <sup>+<\/sup>\n                    Neutrophils Promote Colorectal Cancer Progression by Inhibiting Natural Killer Cells"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5612-1387","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Systems Medicine for Cancer Renji Hospital School of Biomedical Engineering Shanghai 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