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Here, this study presents a novel approach for the targeted treatment of periodontitis utilizing the immunomodulatory and antibacterial properties of Embelin, a plant\u2010derived compound, within an injectable hydrogel system. The developed Carboxymethyl Chitosan\u2010Oxidized Dextran (CMCS\u2010OD) hydrogel formed via dynamic chemical bonds exhibited self\u2010healing capabilities and pH\u2010responsive behavior, thereby facilitating the controlled release of Embelin and enhancing its efficacy in a dynamic oral periodontitis microenvironment. This study demonstrates that this hydrogel system effectively prevents bacterial invasion and mitigates excessive immune response activation. Moreover, it precisely modulates macrophage M1\/M2 phenotypes and suppresses inflammatory cytokine expression, thereby fostering a conducive environment for bone regeneration and addressing periodontitis\u2010induced bone loss. These findings highlight the potential of the approach as a promising strategy for the clinical management of periodontitis\u2010induced bone destruction.<\/jats:p>","DOI":"10.1002\/advs.202403786","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T01:42:28Z","timestamp":1720489348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["A Microenvironment\u2010Responsive, Controlled Release Hydrogel Delivering Embelin to Promote Bone Repair of Periodontitis via Anti\u2010Infection and Osteo\u2010Immune Modulation"],"prefix":"10.1002","volume":"11","author":[{"given":"Guanming","family":"Cai","sequence":"first","affiliation":[{"name":"Hospital of Stomatology Guanghua School of Stomatology Sun Yat\u2010sen University  Guangzhou 510055 P. R. 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