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Human umbilical mesenchymal stem cells\u2010derived exosomes (hUMSCs\u2010Exos) are regarded as promising therapeutic choice for autoimmune diseases due to potent immunosuppressive and anti\u2010oxidative properties, which can be potentiated under 3D cell culture condition. Nevertheless, whether exosomes derived from 3D spheroids of hUMSCs (3D\u2010Exos) exhibit considerable therapeutic effect on vitiligo and the underlying mechanism remain elusive. In this study, systemic administration of 3D\u2010Exos showed a remarkable effect in treating mice with vitiligo, as revealed by ameliorated skin depigmentation, less CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells infiltration, and expanded Treg cells in skin, and 3D\u2010Exos exerted a better effect than 2D\u2010Exos. Mechanistically, 3D\u2010Exos can prominently facilitate the expansion of Treg cells in vitiligo lesion and suppress H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced melanocytes apoptosis. Forward miRNA profile analysis and molecular experiments have demonstrated that miR\u2010132\u20103p and miR\u2010125b\u20105p enriched in 3D\u2010Exos greatly contributed to these biological effects by targeting\n                    <jats:italic>Sirt1<\/jats:italic>\n                    and\n                    <jats:italic>Bak1<\/jats:italic>\n                    respectively. In aggregate, 3D\u2010Exos can efficiently ameliorate vitiligo by simultaneously potentiating Treg cells\u2010mediated immunosuppression and suppressing oxidative stress\u2010induced melanocyte damage via the delivery of miR\u2010132\u20103p and miR\u2010125b\u20105p. The employment of 3D\u2010Exos will be a promising treament for vitiligo.\n                  <\/jats:p>","DOI":"10.1002\/advs.202404064","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T01:44:52Z","timestamp":1718675092000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["3D\u2010hUMSCs Exosomes Ameliorate Vitiligo by Simultaneously Potentiating Treg Cells\u2010Mediated Immunosuppression and Suppressing Oxidative Stress\u2010Induced Melanocyte Damage"],"prefix":"10.1002","volume":"11","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University  Xi'an Shaanxi 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weinan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University 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