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Neuropsychiatric symptoms are commonly manifested in cerebral amyloid angiopathy patients but are usually considered as consequences of cerebral amyloid angiopathy pathology. Here, it is reported that chronic stress promotes cerebral amyloid angiopathy progression, which enhances deposition of amyloid protein beta (A\u03b2) in brain blood vessels and exacerbates subsequent brain injury. Mechanistically, neutrophil is implicated in cerebral amyloid angiopathy development. A\u03b2 that accumulates in brain vasculature induces neutrophil extracellular traps (NETs) by activating STAT6 signaling, which inhibits neutrophil apoptosis and switches the programmed cell death toward NETosis. During chronic stress, circulatory Norepinephrine (NE) strengthens STAT6 activation in neutrophil and promotes NET formation, thus exacerbates the NET\u2010dependent angiopathy. It is demonstrated that inhibiting neutrophil chemotaxis towards brain or suppressing NET formation both ameliorate cerebral amyloid angiopathy severity in the context of chronic stress. Therefore, it is proposed that stress\u2010associated psychological disorders and NETs are promising therapeutic targets in cerebral amyloid angiopathy.<\/jats:p>","DOI":"10.1002\/advs.202404096","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T08:08:28Z","timestamp":1727338108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Chronic Stress Exacerbates Cerebral Amyloid Angiopathy Through Promoting Neutrophil Extracellular Traps Formation"],"prefix":"10.1002","volume":"11","author":[{"given":"Huipeng","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurology Mental and Neurological Disease Research Center The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology 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