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Based on the challenge of periodontal bone regeneration treatment and the absence of real\u2010time feedback of blood oxygen fluctuation in diabetes mellitus, a novel self\u2010adaptive hyperthermia supramolecular cascade nano\u2010reactor ACFDG is constructed via one\u2010step supramolecular self\u2010assembly strategy to address multiple factors in diabetic periodontal bone regeneration. Hyperthermia supramolecular ACFDG possesses high photothermal conversion efficiency (32.1%), and it can effectively inhibit the vicious cycle of ROS\u2010inflammatory cascade through catalytic cascade reactions, up\u2010regulate the expression of heat shock proteins (HSPs) under near\u2010infrared (NIR) irradiation, which promotes periodontal bone regeneration. Remarkably, ACFDG can provide real\u2010time non\u2010invasive diagnosis of blood oxygen changes during periodontal bone regeneration through photoacoustic (PA) imaging, thus can timely monitor periodontal hypoxia status. In conclusion, this multifunctional supramolecular nano\u2010reactor combined with PA imaging for real\u2010time efficacy monitoring provides important insights into the biological mechanisms of diabetic periodontal bone regeneration and potential clinical theranostics.<\/jats:p>","DOI":"10.1002\/advs.202404143","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T06:09:28Z","timestamp":1716530968000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Photoacoustic Imaging\u2010Guided Self\u2010Adaptive Hyperthermia Supramolecular Cascade Nano\u2010Reactor for Diabetic Periodontal Bone Regeneration"],"prefix":"10.1002","volume":"11","author":[{"given":"Miao","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University  Chengdu 610065 P. R. 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