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Therefore, an optimal treatment strategy should aim to eliminate the inflammatory response in the joints and simultaneously restore the immune tolerance of Tregs in peripheral blood. Accordingly, we developed an efferocytosis\u2010mimicking nanovesicle that contains three functional factors for immunomodulating of efferocytosis, including \u201cfind me\u201d and \u201ceat me\u201d signals for professional (macrophage) or non\u2010professional phagocytes (T lymphocyte), and \u201capoptotic metabolite\u201d for metabolite digestion. We showed that efferocytosis\u2010mimicking nanovesicles targeted the inflamed joints and spleen of mice with collagen\u2010induced arthritis, further recruiting and selectively binding to macrophages and T lymphocytes to induce M2 macrophage polarization and Treg differentiation and T helper cell 17 (Th17) recession. Under systemic administration, the efferocytosis\u2010mimicking nanovesicles effectively maintained the pro\u2010inflammatory M1\/anti\u2010inflammatory M2 macrophage balance in joints and the Treg\/Th17 imbalance in peripheral blood to prevent RA progression. This study demonstrates the potential of efferocytosis\u2010mimicking nanovesicles for RA immunotherapy.<\/jats:p>","DOI":"10.1002\/advs.202404198","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T14:48:16Z","timestamp":1716994096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Engineering Efferocytosis\u2010Mimicking Nanovesicles to Regulate Joint Anti\u2010Inflammation and Peripheral Immunosuppression for Rheumatoid Arthritis Therapy"],"prefix":"10.1002","volume":"11","author":[{"given":"Shanshan","family":"Yuan","sequence":"first","affiliation":[{"name":"Joint Centre of Translational Medicine The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 325000 China"},{"name":"Joint Centre of Translational Medicine Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang 325000 China"},{"name":"Zhejiang Engineering Research Center 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