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Although medications that target vascular endothelial growth factor (VEGF) are approved for treating CNV, their effectiveness in destroying new blood vessels is limited, and invasive intravitreal administration is required. Additionally, other drugs that destroy established neovessels, such as combretastatin A\u20104, may have systemic side effects that limit their therapeutic benefits. To overcome these shortcomings, a two\u2010pronged anti\u2010vascular approach is presented for CNV treatment using a photoactivatable nanoparticle system that can release a VEGF receptor inhibitor and a vascular disrupting agent when irradiated with 690\u00a0nm light. The nanoparticles can be injected intravenously to enable anti\u2010angiogenic and vascular disrupting combination therapy for CNV through light irradiation to the eyes. 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