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However, their clinical efficacy is hindered by the suboptimal pharmacokinetics and the strong self\u2010rescue of tumor cells. To overcome these limitations, reactive oxygen species (ROS)\u2010responsive nanoparticles (NPs) are designed that encapsulate HDACi MS\u2010275 and the glutamine metabolism inhibitor V\u20109302. Upon reaching the tumor microenvironment, these NPs can disintegrate, thereby releasing MS\u2010275 to increase the level of ROS and V\u20109302 to reduce the production of glutathione (GSH) related to self\u2010rescue. These synergistic effects lead to a lethal ROS storm and induce cell pyroptosis. When combined with programmed cell death protein 1 monoclonal antibodies (<jats:italic>\u03b1<\/jats:italic>\u2010PD\u20101), these NPs facilitate immune cell infiltration, improving anti\u2010tumor immunity, converting \u201cimmune\u2010cold\u201d tumors into \u201cimmune\u2010hot\u201d tumors, and enhancing immune memory in mice. The findings present a nano\u2010delivery strategy for the co\u2010delivery of epigenetic therapeutics and metabolic inhibitors, which induces pyroptosis in tumors cells and improves the effectiveness of chemotherapy and immunotherapy.<\/jats:p>","DOI":"10.1002\/advs.202404375","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T15:20:24Z","timestamp":1718724024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Co\u2010delivery Nano System of MS\u2010275 and V\u20109302 Induces Pyroptosis and Enhances Anti\u2010Tumor Immunity Against Uveal Melanoma"],"prefix":"10.1002","volume":"11","author":[{"given":"Hong","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Ophthalmology The Third Xiangya Hospital Central South University  Changsha Hunan 410013 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