{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:46:17Z","timestamp":1792266377405,"version":"4.4.0"},"reference-count":58,"publisher":"Wiley","issue":"36","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Microbial tryptophan (Trp) metabolites acting as aryl hydrocarbon receptor (AhR) ligands are shown to effectively improve metabolic diseases via regulating microbial community. However, the underlying mechanisms by which Trp metabolites ameliorate bone loss via gut\u2010bone crosstalk are largely unknown. In this study, supplementation with Trp metabolites, indole acetic acid (IAA), and indole\u20103\u2010propionic acid (IPA), markedly ameliorate bone loss by repairing intestinal barrier integrity in ovariectomy (OVX)\u2010induced postmenopausal osteoporosis mice in an AhR\u2010dependent manner. Mechanistically, intestinal AhR activation by Trp metabolites, especially IAA, effectively repairs intestinal barrier function by stimulating Wnt\/\u03b2\u2010catenin signaling pathway. Consequently, enhanced M2 macrophage by supplementation with IAA and IPA secrete large amount of IL\u201010 that expands from intestinal lamina propria to bone marrow, thereby simultaneously promoting osteoblastogenesis and inhibiting osteoclastogenesis in vivo and in vitro. Interestingly, supplementation with Trp metabolites exhibit negligible ameliorative effects on both gut homeostasis and bone loss of OVX mice with intestinal AhR knockout (Villin\n                    <jats:sup>Cre<\/jats:sup>\n                    Ahr\n                    <jats:sup>fl\/fl<\/jats:sup>\n                    ). These findings suggest that microbial Trp metabolites may be potential therapeutic candidates against osteoporosis via regulating AhR\u2010mediated gut\u2010bone axis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202404545","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T16:16:34Z","timestamp":1721751394000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Microbial Tryptophan Metabolites Ameliorate Ovariectomy\u2010Induced Bone Loss by Repairing Intestinal AhR\u2010Mediated Gut\u2010Bone Signaling Pathway"],"prefix":"10.1002","volume":"11","author":[{"given":"Chuan","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Magnetic Resonance and Imaging National Centre for Magnetic Resonance in Wuhan Innovation Academy of Precision Measurement Science and Technology CAS  Wuhan 430071 China"},{"name":"University of Chinese Academy of Sciences  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