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In contrast, NPs in nanomedicine hold great promise for precise lung\u2010specific drug delivery, especially considering the extensive pulmonary capillary network that facilitates interactions with bloodstream\u2010suspended particles. Therefore, exact knowledge about effects of engineered NPs within the pulmonary microcirculation are instrumental for future application of this technology in patients. To unravel the real\u2010time dynamics of intravenously delivered NPs and their effects in the pulmonary microvasculature, we employed intravital microscopy of the mouse lung. Only PEG\u2010amine\u2010QDs, but not carboxyl\u2010QDs triggered rapid neutrophil recruitment in microvessels and their subsequent recruitment to the alveolar space and was linked to cellular degranulation, TNF\u2010\u03b1, and DAMP release into the circulation, particularly eATP. 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