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Unfortunately, there are no clinically approved drugs available for its treatment. Recent studies have illuminated the pivotal role of macrophage recruitment in the pathogenesis of liver fibrosis, presenting a potential therapeutic target. Therefore, it holds great promise to develop novel anti\u2010fibrotic therapies capable of inhibiting this process. Herein, a drug\u2010loaded biomimetic nanodecoy (CNV\u2010C) is developed by harnessing genetically engineered cellular vesicles for the treatment of liver fibrosis. CNV\u2010C is equipped with a C\u2010C motif chemokine receptor 2 (CCR2)\u2010overexpressed surface, enabling it to selectively neutralize elevated levels of C\u2010C motif chemokine ligand 2 (CCL2), thereby reducing macrophage infiltration and the subsequent production of the fibrogenic cytokine transforming growth factor \u03b2 (TGF\u2010\u03b2). Moreover, curcumin, an anti\u2010fibrotic agent, is loaded into CNV\u2010C and delivered to the liver, facilitating its efficacy in suppressing the activation of hepatic stellate cells by blocking the downstream TGF\u2010\u03b2\/Smad signaling. This combinational therapy ultimately culminates in the alleviation of liver fibrosis in a mouse model induced by carbon tetrachloride. Collectively, the findings provide groundbreaking proof\u2010of\u2010concept for employing genetically modified nanodecoys to manage liver fibrosis, which may usher in a new era of anti\u2010fibrotic treatments.<\/jats:p>","DOI":"10.1002\/advs.202405026","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T07:44:15Z","timestamp":1724917455000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Genetically Engineered Biomimetic Nanodecoy for the Treatment of Liver Fibrosis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4173-1793","authenticated-orcid":false,"given":"Yang","family":"Du","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou 310009 China"},{"name":"Key Laboratory of Precision Diagnosis and Treatment for 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