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However, the precise mechanism triggering the initiation of signaling in the pro\u2010regenerative niche remains unknown. Using single\u2010cell RNA sequencing, 14 different muscle cells are comprehensively mapped during the initial stage following injury. Among these, macrophages and fibro\u2010adipogenic progenitor cells (FAPs) exhibit the most pronounced intercellular communication with other cells. In the FAP subclusters, the study identifies an activated FAP phenotype that secretes chemokines, such as CXCL1, CXCL5, CCL2, and CCL7, to recruit macrophages after injury. <jats:italic>Il1rl1<\/jats:italic>, encoding the protein of the interleukin\u201033 (IL\u201033) receptor, is identified as a highly expressed signature surface marker of the FAP phenotype. Following muscle injury, autocrine IL\u201033, an alarmin, has been observed to activate quiescent FAPs toward this inflammatory phenotype through the IL1RL1\u2010MAPK\/NF\u2010\u03baB signaling pathway. <jats:italic>Il1rl1<\/jats:italic> deficiency results in decreased chemokine expression and recruitment of macrophages, accompanied by impaired muscle regeneration. These findings elucidate a novel mechanism involving the IL\u201033\/IL1RL1 signaling pathway in promoting the activation of FAPs and facilitating muscle regeneration, which can aid the development of therapeutic strategies for muscle\u2010related disorders and injuries.<\/jats:p>","DOI":"10.1002\/advs.202405299","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T12:40:35Z","timestamp":1721652035000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["IL\u201033 Facilitates Fibro\u2010Adipogenic Progenitors to Establish the Pro\u2010Regenerative Niche after Muscle Injury"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4932-3412","authenticated-orcid":false,"given":"Congcong","family":"Zhang","sequence":"first","affiliation":[{"name":"Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases  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