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Nevertheless, the effectiveness of these substances is frequently limited in many patients due to poor adherence, short retention time in the mouth, and less\u2010than\u2010optimal drug efficacy. In this study, a new hydrogel patch (FSH3) made of a silk fibroin\/hyaluronic acid matrix with light\u2010sensitive adhesive qualities infused with ferric iron\/shikonin nanoparticles to enhance healing effects is presented. Initially, this hydrogel forms an adhesive barrier over mucosal lesions through a straightforward local injection, solidifying when exposed to UV light. Subsequently, FSH3 demonstrates superior reactive oxygen species elimination and near\u2010infrared photothermal bactericidal activity. These characteristics support bacterial elimination and regulate oxidative levels, promoting a wound's progression from inflammation to tissue regeneration. In a diabetic rat model mimicking oral ulcers, FSH3 significantly speeds up healing by adjusting the inflammatory environment of the injured tissue, maintaining balance in oral microbiota, and promoting faster re\u2010epithelialization. Overall, the light\u2010sensitive FSH3 hydrogel shows potential for rapid wound recovery and may transform therapeutic methods for managing oral ulcers in diabetes.<\/jats:p>","DOI":"10.1002\/advs.202405463","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T09:34:33Z","timestamp":1728639273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Ferric Iron\/Shikonin Nanoparticle\u2010Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes"],"prefix":"10.1002","volume":"11","author":[{"given":"Xiaojing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 325000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangping","family":"Li","sequence":"additional","affiliation":[{"name":"The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People's Hospital  Quzhou 324000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XinXin","family":"Ge","sequence":"additional","affiliation":[{"name":"School &amp; 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