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The early diagnosis of infection and the treatment of advanced AE remain challenging. Herein, bulk RNA\u2010seq, scRNA\u2010seq, and spatial transcriptomics technologies are integrated, to reveal the host immune response mechanism against\n                    <jats:italic>E. multilocularis<\/jats:italic>\n                    both spatially and chronologically, collecting mouse liver samples at multiple timepoints up to 15 months post infection. These results unveil an unprecedented high\u2010resolution spatial atlas of the\n                    <jats:italic>E. multilocularis<\/jats:italic>\n                    infection foci and the functional roles of neutrophils,\n                    <jats:italic>\n                      Spp1\n                      <jats:sup>+<\/jats:sup>\n                    <\/jats:italic>\n                    macrophages, and fibroblasts during disease progression. The heterogeneity of neutrophil and macrophage subpopulations are critical in both parasite\u2010killing and the occurrence of immunosuppression during AE progression. These findings indicate the transition of parasite control strategy from \u201cactive killing\u201d to \u201cnegative segregation\u201d by the host, providing instructive insights into the treatment strategy for echinococcosis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202405914","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T03:32:36Z","timestamp":1740195156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Spatiotemporal Transcriptomic Profiling Reveals the Dynamic Immunological Landscape of Alveolar Echinococcosis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1479-9007","authenticated-orcid":false,"given":"Zhihua","family":"Ou","sequence":"first","affiliation":[{"name":"BGI Research  Beijing 102601 China"},{"name":"Shenzhen Key Laboratory of Unknown Pathogen Identification BGI Research  Shenzhen 518083 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