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Therefore, strategies to simultaneously increase lubrication and relieve inflammation to remodel the damaged articular microenvironment are of great significance for enhancing its treatment. Herein, a multifunctional core\u2010brush nanoplatform composed of a ROS\u2010scavenging polydopamine\u2010coated SiO\n                    <jats:sub>2<\/jats:sub>\n                    core and lubrication\u2010enhancing zwitterionic poly(2\u2010methacryloyloxyethyl phosphorylcholine) (PMPC) brush and loaded with the anti\u2010inflammatory drug curcumin by a reactive oxygen species (ROS)\u2010liable conjugation (named as SiO\n                    <jats:sub>2<\/jats:sub>\n                    @PP\u2010Cur) is rationally designed. Benefiting from the grafted zwitterionic PMPC brush, a tenacious hydration layer with enhanced lubricity for reducing joint abrasions is developed. More importantly, based on the mono\u2010iodoacetic acid\u2010induced arthritis (MIA) rat model, intra\u2010articular injection of SiO\n                    <jats:sub>2<\/jats:sub>\n                    @PP\u2010Cur nanoplatform can effectively alleviate articular inflammation via promoting macrophage polarization from the pro\u2010inflammatory M1 to anti\u2010inflammatory M2 state by activating the nuclear factor erythroid 2\u2010related factor 2 (Nrf2) signaling pathway and attenuating the degradation of cartilage matrix, resulting in the remodeling of the damaged microenvironment into a pro\u2010regenerative microenvironment. As a result, SiO\n                    <jats:sub>2<\/jats:sub>\n                    @PP\u2010Cur can considerably inhibit OA progression. Therefore, the work may provide a novel strategy for the development of an advanced core\u2010brush nanoplatform for enhanced OA therapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202406027","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T06:41:35Z","timestamp":1730443295000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["A Core\u2010Brush Nanoplatform with Enhanced Lubrication and Anti\u2010Inflammatory Properties for Osteoarthritis Treatment"],"prefix":"10.1002","volume":"11","author":[{"given":"Yingying","family":"Liu","sequence":"first","affiliation":[{"name":"Biomedical Sciences College Shandong Medicinal Biotechnology Centre Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong 250117 China"},{"name":"Medical Science and Technology Innovation Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong 250117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyan","family":"Ma","sequence":"additional","affiliation":[{"name":"Medical Science and Technology Innovation Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong 250117 China"},{"name":"School of Public Health Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong 250117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Biomedical Sciences College Shandong Medicinal Biotechnology Centre Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong 250117 China"},{"name":"Faculty of Light Industry, State Key Laboratory of Biobased Material and Green Papermaking Qilu University of Technology (Shandong Academy of Sciences)  Jinan 250353 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Liang","sequence":"additional","affiliation":[{"name":"Medical Science and Technology Innovation Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong 250117 China"},{"name":"School of Public Health Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong 250117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Medical Science and Technology Innovation Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong 250117 China"},{"name":"School of Public Health Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong 250117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Science and Technology Innovation Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong 250117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Ren","sequence":"additional","affiliation":[{"name":"Medical Science and Technology Innovation Center Shandong First Medical University &amp; 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