{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:31:14Z","timestamp":1791228674902,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2020YFA0908100"],"award-info":[{"award-number":["2020YFA0908100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971724"],"award-info":[{"award-number":["81971724"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173750"],"award-info":[{"award-number":["82173750"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82141215"],"award-info":[{"award-number":["82141215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005049","name":"Science and Engineering Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hypoxia, inflammatory response and pathogen (bacterial or viral) infection are the three main factors that lead to death in patients with acute lung injury (ALI). Among them, hypoxia activates the expression of HIF\u20101\u03b1, further exacerbating the production of ROS and inflammatory response. Currently, anti\u2010inflammatory and pathogen elimination treatment strategies have effectively alleviated infectious pneumonia, but improving lung hypoxia still faces challenges. Here, a vancomycin\u2010loaded nanoventilator (SCVN) containing superoxide dismutase (SOD) and catalase (CAT) is developed, which is prepared by encapsulating SOD, CAT and vancomycin into a nanocapsule by in situ polymerization. This nanocapsule can effectively improve the stability and loading rate of enzymes, and enhance their enzyme cascade efficiency, thereby efficiently consuming \u2022O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    to generate O\n                    <jats:sub>2<\/jats:sub>\n                    in situ and reducing ROS level. More interestingly, in situ O\n                    <jats:sub>2<\/jats:sub>\n                    supply can effectively relieve lung hypoxia to reduce HIF\u20101\u03b1 expression and balance the number of M1\/M2 macrophages to reduce the levels of TNF\u2010\u03b1, IL\u20101\u03b2 and IL\u20106, thereby alleviating the inflammatory response. Meanwhile, vancomycin can target and kill MRSA, fundamentally solving the cause of pneumonia. This nanoventilator with antibacterial, anti\u2010inflammatory, ROS scavenging and in situ O\n                    <jats:sub>2<\/jats:sub>\n                    supply functions will provide a universal clinical treatment strategy for ALI caused by pathogens.\n                  <\/jats:p>","DOI":"10.1002\/advs.202406060","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T12:54:36Z","timestamp":1742388876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["ROS\u2010Driven Nanoventilator for MRSA\u2010Induced Acute Lung Injury Treatment via In Situ Oxygen Supply, Anti\u2010Inflammation and Immunomodulation"],"prefix":"10.1002","volume":"12","author":[{"given":"Zheng","family":"Luo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology Fujian Provincial Key Laboratory of Innovative Drug Target Research School of Pharmaceutical Sciences Xiamen University  Xiamen 361102 China"},{"name":"Institute of Materials Research and Engineering (IMRE) Agency for Science Technology and Research (A*STAR)  2 Fusionopolis Way, Innovis #08\u201003 Singapore 138634 Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology Fujian Provincial Key Laboratory of Innovative Drug Target Research School of Pharmaceutical Sciences Xiamen University  Xiamen 361102 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Sustainability for Chemicals Energy and Environment (ISCE2) Agency for Science, Technology and Research (A*STAR)  1 Pesek Road, Jurong Island Singapore 627833 Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue Qi","family":"Koh","sequence":"additional","affiliation":[{"name":"Institute of Materials Research and Engineering (IMRE) Agency for Science Technology and Research (A*STAR)  2 Fusionopolis Way, Innovis #08\u201003 Singapore 138634 Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian Jun","family":"Loh","sequence":"additional","affiliation":[{"name":"Institute of Materials Research and Engineering (IMRE) Agency for Science Technology and Research (A*STAR)  2 Fusionopolis Way, Innovis #08\u201003 Singapore 138634 Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caisheng","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology Fujian Provincial Key Laboratory of Innovative Drug Target Research School of Pharmaceutical Sciences Xiamen University  Xiamen 361102 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0591-5328","authenticated-orcid":false,"given":"Zibiao","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Materials Research and Engineering (IMRE) Agency for Science Technology and Research (A*STAR)  2 Fusionopolis Way, Innovis #08\u201003 Singapore 138634 Republic of Singapore"},{"name":"Institute of Sustainability for Chemicals Energy and Environment (ISCE2) Agency for Science, Technology and Research (A*STAR)  1 Pesek Road, Jurong Island Singapore 627833 Republic of Singapore"},{"name":"Department of Materials Science and Engineering National University of Singapore  Singapore 117576 Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Long","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology Fujian Provincial Key Laboratory of Innovative Drug Target Research School of Pharmaceutical Sciences Xiamen University  Xiamen 361102 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.03.005"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx090"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.F278"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00024.2020"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0138-2021"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2011.00065"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.supplement_1.4"},{"key":"e_1_2_8_3_3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.669539"},{"key":"e_1_2_8_3_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27428-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0137TR"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.653969"},{"key":"e_1_2_8_4_3","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-007-0280-4"},{"key":"e_1_2_8_4_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00886-y"},{"key":"e_1_2_8_4_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.08.002"},{"key":"e_1_2_8_4_6","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00670-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.1c00866"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127872"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121768"},{"key":"e_1_2_8_5_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.02.017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.88.4_Supplement.229S"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.10.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06459-2"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1916431"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau9959"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.88.6.900"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anbr.202200110"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2NR04171E"},{"key":"e_1_2_8_9_3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202105837"},{"key":"e_1_2_8_9_4","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b01784"},{"key":"e_1_2_8_9_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121943"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.02.033"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201401559"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.01.056"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR06214J"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111721"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00100.2021"},{"key":"e_1_2_8_12_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.10.032"},{"key":"e_1_2_8_12_4","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-015-2566-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.04.003"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/510386"},{"key":"e_1_2_8_13_3","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00700-07"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00271D"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10020313"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01452-1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0121-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1387-2656(05)11004-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.08.029"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c10575"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b17509"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202406060","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202406060","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202406060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:49:59Z","timestamp":1788529799000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202406060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,19]]},"references-count":49,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/advs.202406060"],"URL":"https:\/\/doi.org\/10.1002\/advs.202406060","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,19]]},"assertion":[{"value":"2024-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2406060"}}