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Traditional therapies targeting specific cytokines or ROS often prove inadequate. An innovative drug delivery system (DDS) is developed using neutrophil decoys (NDs) that encapsulate 18\u03b2\u2010glycyrrhetinic acid (GA) within a hydrolyzable oxalate polymer (HOP) and neutrophil membrane vesicles (NMVs). These NDs are responsive to hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>), enabling controlled GA release. Additionally, NDs adsorb inflammatory factors, thereby reducing inflammation. They exhibit enhanced adhesion to inflamed endothelial cells (ECs) and improved penetration. Once internalized by cardiomyocytes through clathrin\u2010mediated endocytosis, NDs protect against ROS\u2010induced damage and inhibit HMGB1 translocation. In vivo studies show that NDs preferentially accumulate in injured myocardium, reducing infarct size, mitigating adverse remodeling, and enhancing cardiac function, all while maintaining favorable biosafety profiles. This neutrophil\u2010based system offers a promising targeted therapy for MI\/RI by addressing both inflammation and ROS, holding potential for future clinical applications.<\/jats:p>","DOI":"10.1002\/advs.202406124","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T11:24:15Z","timestamp":1726140255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Enhancing Cardioprotection Through Neutrophil\u2010Mediated Delivery of 18\u03b2\u2010Glycyrrhetinic Acid in Myocardial Ischemia\/Reperfusion Injury"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0236-8410","authenticated-orcid":false,"given":"Dongjian","family":"Han","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Zhengzhou University  Zhengzhou 450052 China"},{"name":"Key Laboratory of Cardiac Injury and Repair of Henan Province  Zhengzhou 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