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Here, it is reported that mice subjected to CP exhibited depression\u2010like behaviors and hippocampal memory deficits, accompanied by synapse loss and neurogenesis impairment in the hippocampus. RNA microarray analysis disclosed that albumin D\u2010site\u2010binding protein (DBP) is identified as the most prominently upregulated target gene following CP, and in\u00a0vivo\u00a0and in\u00a0vitro immunofluorescence methods showed that DBP is preferentially expressed in microglia but not neurons or astrocytes in the hippocampus. Interestingly, it is found that the expression of DBP is significantly increased in microglia after CP, and knockdown of microglial DBP ameliorated the behavioral abnormality, as well as reversed the synapse loss and hippocampal\u00a0neurogenesis damage induced by CP. Furthermore, DBP knockdown improved the CP\u2010induced hippocampal inflammation and microglial polarization. Collectively, these results indicate a critical role of DBP in orchestrating chronic periodontitis\u2010related behavioral abnormality, hippocampal synapse loss and\u00a0neurogenesis deficits, in which the microglial activation may be indispensably involved.<\/jats:p>","DOI":"10.1002\/advs.202406269","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T04:59:58Z","timestamp":1729486798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Microglial DBP Signaling Mediates Behavioral Abnormality Induced by Chronic Periodontitis in Mice"],"prefix":"10.1002","volume":"11","author":[{"given":"Ting","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Children's Stomatology Stomatological Hospital of Xiamen Medical College, Xiamen Key Laboratory of Stomatological Disease Diagnosis and Treatment  Xiamen 361003 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