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This study aims to elucidate the effects and mechanisms of typical metallic QDs on retinas using zebrafish. Comprehensive histology, imaging, and bulk RNA sequencing reveal that InP\/ZnS QDs cause retinal degeneration. Furthermore, single\u2010cell RNA\u2010seq reveals a reduction in the number of retinal pigment epithelial cells (RPE) and short\u2010wave cone UV photoreceptor cells (PR(UV)), accompanied by an increase in middle\u2010 and long\u2010wave cone red, green, and blue photoreceptor cells [PR(RGB)]. Mechanistically, after endocytosis by RPE, InP\/ZnS QDs inhibit the expression of splicing factor <jats:italic>prpf8<\/jats:italic>, resulting in <jats:italic>gpx4b<\/jats:italic> mRNA unsplicing, which finally decrease glutathione and induce ferroptosis and mitophagy. The decrease of RPE fails to engulf the damaged outer segments of PR, possibly promoting the differentiation of PR(UV) to PR(RGB). Knockout <jats:italic>prpf8<\/jats:italic> or <jats:italic>gpx4b<\/jats:italic> with CRISPR\/Cas9 system, the retinal damage is also observed. Whereas, overexpression of <jats:italic>prpf8<\/jats:italic> or <jats:italic>gpx4b<\/jats:italic>, or supplement of glutathione can rescue the retinal degenerative damage caused by InP\/ZnS QDs. In conclusion, this study illustrates the potential health risks of InP\/ZnS QDs on eye development and provides valuable insights into the underlying mechanisms of InP\/ZnS QDs\u2010caused retinal degeneration.<\/jats:p>","DOI":"10.1002\/advs.202406343","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:45:17Z","timestamp":1729212317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Quantum Dots\u2010caused Retinal Degeneration in Zebrafish Regulated by Ferroptosis and Mitophagy in Retinal Pigment Epithelial Cells through Inhibiting Spliceosome"],"prefix":"10.1002","volume":"11","author":[{"given":"Naying","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology in Xiang'an Hospital of Xiamen University State Key Laboratory of Cellular Stress Biology School of Life Sciences Faculty of Medicine and Life Sciences Xiamen University  Xiamen 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